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Tchem
CTSK
Cathepsin K

Protein Summary
Description
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271651
  • ENSP00000271651
  • ENSG00000143387

Symbol
  • CTSO
  • CTSO2
  • CTSO
  • PKND
  • PYCD
  • CTS02
  • CTSO1
  • CTSO2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological term
0.84
cellular component
0.8
drug
0.79
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1290.09   (req: < 5)
Gene RIFs: 128   (req: <= 3)
Antibodies: 548   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1290.09   (req: >= 5)
Gene RIFs: 128   (req: > 3)
Antibodies: 548   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1392
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (54)
1 – 5 of 54
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (313)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Adaptive Immune System
Reactome
Collagen degradation
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Adaptive Immune System
Collagen degradation
Degradation of the extracellular matrix
Extracellular matrix organization
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (171)
1 – 10 of 171
ARID4B
Tbio
Family: TF; Epigenetic
Novelty: 0.04182223
p_int: 0.999931433
p_ni: 0.000068552
p_wrong: 1.5e-8
Score: 0.306
Data Source: BioPlex,STRINGDB
CTSL
Tclin
Family: Enzyme
Novelty: 0.00058727
p_int: 0.971383533
p_ni: 0.028215006
p_wrong: 0.000401462
Score: 0.841
Data Source: BioPlex,STRINGDB
C18orf25
Tdark
Novelty: 0.67505268
p_int: 0.952833038
p_ni: 0.047013558
p_wrong: 0.000153405
Score: 0.261
Data Source: BioPlex,STRINGDB
CTSV
Tchem
Family: Enzyme
Novelty: 0.00916301
p_int: 0.944256157
p_ni: 0.055743843
Score: 0.572
Data Source: BioPlex,STRINGDB
ERBIN
Tbio
Novelty: 0.01419561
p_int: 0.937258817
p_ni: 0.062741183
Score: 0.339
Data Source: BioPlex,STRINGDB
TNFSF11
Tclin
Novelty: 0.00018328
Score: 0.962
Data Source: STRINGDB
MMP13
Tchem
Family: Enzyme
Novelty: 0.00057893
Score: 0.958
Data Source: Reactome,STRINGDB
SERPINB13
Tbio
Novelty: 0.01753451
Score: 0.95
Data Source: Reactome,STRINGDB
CD74
Tchem
Novelty: 0.00281228
Score: 0.938
Data Source: STRINGDB
MMP7
Tchem
Family: Enzyme
Novelty: 0.00080093
Score: 0.938
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1290.09

PubMed score by year
PubTator Score  777.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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