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Tbio
PSMB6
Proteasome subunit beta type-6

Protein Summary
Description
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolizing activity also termed ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270586
  • ENSP00000270586
  • ENSG00000142507

Symbol
  • LMPY
  • Y
  • Y
  • LMPY
  • DELTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
kinase perturbation
0.95
transcription factor perturbation
0.91
co-expressed gene
0.89
interacting protein
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.4   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.4   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (30)
1 – 5 of 30
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (154)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 148
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (302)
1 – 10 of 302
PSMA5
Tbio
Family: Enzyme
Novelty: 0.05889678
p_int: 0.999440724
p_ni: 0.000559276
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMB2
Tclin
Family: Enzyme
Novelty: 0.15790562
p_int: 0.998040299
p_ni: 0.001959701
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMB1
Tclin
Family: Enzyme
Novelty: 0.04143829
p_int: 0.99456549
p_ni: 0.00543451
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMB7
Tbio
Family: Enzyme
Novelty: 0.13674668
p_int: 0.974127129
p_ni: 0.025872871
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMB4
Tbio
Family: Enzyme
Novelty: 0.06608783
p_int: 0.959442087
p_ni: 0.040557913
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMB3
Tdark
Family: Enzyme
Novelty: 0.2736908
p_int: 0.93685997
p_ni: 0.06314003
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMC5
Tbio
Family: Enzyme
Novelty: 0.01964643
Score: 0.999
Data Source: STRINGDB
PSMB5
Tclin
Family: Enzyme
Novelty: 0.02980971
Score: 0.999
Data Source: STRINGDB
PSMD2
Tbio
Family: Enzyme
Novelty: 0.02196206
Score: 0.999
Data Source: STRINGDB
PSMC4
Tbio
Family: Enzyme
Novelty: 0.02568601
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.40

PubMed score by year
PubTator Score  4.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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