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Tdark
KLHDC4
Kelch domain-containing protein 4

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270583
  • ENSP00000270583
  • ENSG00000104731
  • ENST00000347925
  • ENSP00000325717
  • ENST00000353170
  • ENSP00000262530
  • ENST00000567298
  • ENSP00000457570
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor binding site profile
0.84
cell type or tissue
0.78
cellular component
0.75
cell line
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.6   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.6   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Cleft palate
1
1
0
1.3
49.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Cleft palate
0
1.3
49.3
Protein-Protein Interactions (51)
1 – 10 of 51
CROT
Tbio
Family: Enzyme
Novelty: 0.01860427
p_int: 0.998419702
p_ni: 0.00000291
p_wrong: 0.001577389
Score: 0.485
Data Source: BioPlex,STRINGDB
POLR1B
Tbio
Family: Enzyme
Novelty: 0.06955307
Score: 0.808
Data Source: STRINGDB
BOP1
Tbio
Novelty: 0.03512044
Score: 0.734
Data Source: STRINGDB
ARMC6
Tdark
Novelty: 0.58706267
Score: 0.728
Data Source: STRINGDB
SDAD1
Tdark
Novelty: 0.2574139
Score: 0.683
Data Source: STRINGDB
BMS1
Tbio
Novelty: 0.0349992
Score: 0.652
Data Source: STRINGDB
PUM3
Tbio
Novelty: 0.02344206
Score: 0.64
Data Source: STRINGDB
MAK16
Tdark
Novelty: 0.07717917
Score: 0.639
Data Source: STRINGDB
DMAC1
Tbio
Novelty: 1.16519301
Score: 0.609
Data Source: STRINGDB
BRIX1
Tbio
Novelty: 0.16561444
Score: 0.608
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.60

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer