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Tbio
FXYD7
FXYD domain-containing ion transport regulator 7

Protein Summary
Description
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270310
  • ENSP00000270310
  • ENSG00000221946
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.63
gene perturbation
0.6
molecular function
0.6
PubMedID
0.57
tissue sample
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.93   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.93   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (21)
1 – 10 of 21
ATP1B1
Tclin
Family: Transporter
Novelty: 0.025056
Score: 0.983
Data Source: STRINGDB
ATP1A1
Tclin
Family: Transporter
Novelty: 0.01078788
Score: 0.942
Data Source: STRINGDB
ATP1A3
Tclin
Family: Transporter
Novelty: 0.00485594
Score: 0.937
Data Source: STRINGDB
ATP1A2
Tclin
Family: Transporter
Novelty: 0.00606202
Score: 0.927
Data Source: STRINGDB
ATP1B2
Tclin
Family: Transporter
Novelty: 0.02641193
Score: 0.922
Data Source: STRINGDB
ATP1A4
Tclin
Family: Transporter
Novelty: 0.01011201
Score: 0.92
Data Source: STRINGDB
ATP1B3
Tclin
Family: Transporter
Novelty: 0.06773518
Score: 0.906
Data Source: STRINGDB
FXYD4
Tdark
Family: IC
Novelty: 0.11545177
Score: 0.831
Data Source: STRINGDB
FXYD5
Tbio
Family: IC
Novelty: 0.01598365
Score: 0.719
Data Source: STRINGDB
FXYD3
Tbio
Family: IC
Novelty: 0.01217832
Score: 0.705
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.93

PubMed score by year
PubTator Score  3.07

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer