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Tbio
SOD1
Superoxide dismutase [Cu-Zn]

Protein Summary
Description
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270142
  • ENSP00000270142
  • ENSG00000142168

Symbol
  • ALS
  • SOD
  • ALS1
  • IPOA
  • hSod1
  • HEL-S-44
  • homodimer
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
co-expressed gene
1
disease perturbation
1
kinase perturbation
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2723.65   (req: < 5)
Gene RIFs: 882   (req: <= 3)
Antibodies: 1415   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2723.65   (req: >= 5)
Gene RIFs: 882   (req: > 3)
Antibodies: 1415   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
45.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
45.5
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
superoxide dismutase 1
VGNC:14681
449637
Macaque
superoxide dismutase 1
574096
Mouse
MGI:98351
20655
Rat
RGD:3731
24786
Dog
superoxide dismutase 1
VGNC:46653
403559
Species
Name
OMA
EggNOG
Inparanoid
Chimp
superoxide dismutase 1
Macaque
superoxide dismutase 1
Mouse
Rat
Dog
superoxide dismutase 1
Protein Structure (101 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00441-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 101
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Detoxification of Reactive Oxygen Species
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Gene Ontology Terms (87)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (485)
1 – 10 of 485
MAVS
Tbio
Novelty: 0.00241215
p_int: 0.999991973
p_ni: 0.000008027
Score: 0.21
Data Source: BioPlex,STRINGDB
BCL2L13
Tbio
Novelty: 0.01844825
p_int: 0.999987778
p_ni: 0.000012222
Score: 0.409
Data Source: BioPlex,STRINGDB
CCS
Tbio
Family: Enzyme
Novelty: 0.01379006
p_int: 0.999757702
p_ni: 0.000242298
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
STXBP2
Tbio
Novelty: 0.01896992
p_int: 0.98345631
p_ni: 0.01654354
p_wrong: 1.5e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
CENPV
Tbio
Novelty: 0.00175994
p_int: 0.983046103
p_ni: 0.002000517
p_wrong: 0.014953379
Score: 0.26
Data Source: BioPlex,STRINGDB
PHKA1
Tbio
Family: Kinase
Novelty: 0.02895127
p_int: 0.978263329
p_ni: 0.021732473
p_wrong: 0.000004198
Score: 0.197
Data Source: BioPlex,STRINGDB
APOL2
Tbio
Novelty: 0.06076255
p_int: 0.875646135
p_ni: 0.124353865
Score: 0.188
Data Source: BioPlex,STRINGDB
SOD2
Tbio
Family: Enzyme
Novelty: 0.00084288
Score: 0.998
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.996
Data Source: STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  2723.65

PubMed score by year
PubTator Score  5949.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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