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Tbio
CYP4F22
Cytochrome P450 4F22

Protein Summary
Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269703
  • ENSP00000269703
  • ENSG00000171954
  • ENST00000601005
  • ENSP00000469866

Symbol
  • LI3
  • ARCI5
  • INLNE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.71
cell type or tissue
0.65
gene perturbation
0.65
molecular function
0.53
tissue sample
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.95   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.95   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
32.6
monocyte count
1
1
1
32.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
32.6
monocyte count
1
32.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily F member 22
VGNC:7474
455798
Macaque
cytochrome P450, family 4, subfamily F, polypeptide 22
718303
Mouse
MGI:2445210
320997
Rat
RGD:1308796
299566
Dog
cytochrome P450 family 4 subfamily F member 22
VGNC:50366
484868
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily F member 22
Macaque
cytochrome P450, family 4, subfamily F, polypeptide 22
Mouse
Rat
Dog
cytochrome P450 family 4 subfamily F member 22
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6NT55-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Disease
Protein-Protein Interactions (24)
1 – 10 of 24
NIPAL4
Tbio
Novelty: 0.05110099
Score: 0.917
Data Source: STRINGDB
LIPN
Tbio
Family: Enzyme
Novelty: 0.00135912
Score: 0.878
Data Source: STRINGDB
ALOXE3
Tbio
Family: Enzyme
Novelty: 0.02560954
Score: 0.831
Data Source: STRINGDB
ABCA12
Tbio
Family: Transporter
Novelty: 0.00594736
Score: 0.816
Data Source: STRINGDB
ALOX12B
Tbio
Family: Enzyme
Novelty: 0.02778552
Score: 0.812
Data Source: STRINGDB
PNPLA1
Tbio
Family: Enzyme
Novelty: 0.03127922
Score: 0.789
Data Source: STRINGDB
TGM1
Tchem
Family: Enzyme
Novelty: 0.00103799
Score: 0.731
Data Source: STRINGDB
CERS3
Tbio
Family: TF
Novelty: 0.038629
Score: 0.695
Data Source: STRINGDB
ABHD5
Tbio
Family: Enzyme
Novelty: 0.00806614
Score: 0.623
Data Source: STRINGDB
ELOVL4
Tbio
Novelty: 0.00737822
Score: 0.554
Data Source: STRINGDB
Publication Statistics
PubMed Score  50.95

PubMed score by year
PubTator Score  50.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer