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Tbio
KRT10
Keratin, type I cytoskeletal 10

Protein Summary
Description
Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization. This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269576
  • ENSP00000269576
  • ENSG00000186395

Symbol
  • KPP
  • BIE
  • EHK
  • K10
  • KPP
  • BCIE
  • CK10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
0.95
cell type or tissue
0.86
hub protein
0.75
chemical
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.87   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 1410   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.87   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 1410   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 10
VGNC:9350
468240
Macaque
keratin 10
702153
Mouse
MGI:96685
16661
Rat
RGD:1359092
450225
Dog
keratin 10
VGNC:42516
491006
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 10
Macaque
keratin 10
Mouse
Rat
Dog
keratin 10
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13645-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Protein-Protein Interactions (90)
1 – 10 of 90
KRT1
Tbio
Novelty: 0.00278467
Score: 0.999
Data Source: STRINGDB
KRT77
Tbio
Novelty: 0.01331186
Score: 0.996
Data Source: STRINGDB
KRT5
Tbio
Novelty: 0.00072336
Score: 0.995
Data Source: STRINGDB
KRT2
Tbio
Novelty: 0.01448252
Score: 0.995
Data Source: STRINGDB
KRT16
Tbio
Novelty: 0.00503235
Score: 0.988
Data Source: STRINGDB
PRSS1
Tclin
Family: Enzyme
Novelty: 0.00157396
Score: 0.957
Data Source: STRINGDB
KRT7
Tbio
Novelty: 0.00039796
Score: 0.934
Data Source: STRINGDB
KRT8
Tbio
Novelty: 0.00093008
Score: 0.934
Data Source: STRINGDB
KRT72
Tbio
Novelty: 0.06391566
Score: 0.931
Data Source: STRINGDB
KRT4
Tbio
Novelty: 0.00434637
Score: 0.93
Data Source: STRINGDB
Publication Statistics
PubMed Score  558.87

PubMed score by year
PubTator Score  892.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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