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Tclin
ERBB2
Receptor tyrosine-protein kinase erbB-2

Protein Summary
Description
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and S ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269571
  • ENSP00000269571
  • ENSG00000141736
  • ENST00000406381
  • ENSP00000385185
  • ENST00000541774
  • ENSP00000446466
  • ENST00000584601
  • ENSP00000462438

Symbol
  • HER2
  • MLN19
  • NEU
  • NGL
  • NEU
  • NGL
  • HER2
  • TKR1
  • CD340
  • HER-2
  • MLN 19
  • HER-2/neu
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
molecular function
1
protein domain
1


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30470.22   (req: < 5)
Gene RIFs: 2521   (req: <= 3)
Antibodies: 5131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30470.22   (req: >= 5)
Gene RIFs: 2521   (req: > 3)
Antibodies: 5131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 374
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11
Approved Drugs (11)
1 – 10 of 11
ibrutinib
chemical structure image
neratinib
chemical structure image
acalabrutinib
chemical structure image
trastuzumab emtansine
no chemical structure image available
afatinib
chemical structure image
dacomitinib
chemical structure image
lapatinib
chemical structure image
trastuzumab deruxtecan
no chemical structure image available
tucatinib
chemical structure image
pertuzumab
no chemical structure image available
Active Ligands (374)
1 – 10 of 374
CHEMBL598797
chemical structure image
CHEMBL3290142
chemical structure image
CHEMBL3290148
chemical structure image
CHEMBL1630118
chemical structure image
CHEMBL1630109
chemical structure image
CHEMBL545315,CHEMBL31965
chemical structure image
CHEMBL587723
chemical structure image
tesevatinib
chemical structure image
CHEMBL1630110
chemical structure image
CHEMBL1630107
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
73.4
glomerular filtration rate
1
1
1
66.1
mathematical ability
1
1
1
63.6
1
1
0
1.1
50.6
1
1
0
1.5
44.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
73.4
glomerular filtration rate
1
66.1
mathematical ability
1
63.6
0
1.1
50.6
0
1.5
44.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
erb-b2 receptor tyrosine kinase 2
VGNC:9276
454636
Macaque
erb-b2 receptor tyrosine kinase 2
697573
Mouse
MGI:95410
13866
Rat
RGD:2561
24337
Dog
erb-b2 receptor tyrosine kinase 2
VGNC:40436
403883
Species
Name
OMA
EggNOG
Inparanoid
Chimp
erb-b2 receptor tyrosine kinase 2
Macaque
erb-b2 receptor tyrosine kinase 2
Mouse
Rat
Dog
erb-b2 receptor tyrosine kinase 2
Protein Structure (31 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04626-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 31
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (94)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Axon guidance
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Developmental Biology
Disease
Gene Ontology Terms (67)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (690)
1 – 10 of 690
CD79B
Tclin
Novelty: 0.00227414
p_int: 0.993757296
p_ni: 0.006242702
p_wrong: 1e-9
Score: 0.237
Data Source: BioPlex,STRINGDB
NAALADL2
Tbio
Family: Enzyme
Novelty: 0.17299124
p_int: 0.936910274
p_ni: 0.063089726
Score: 0.373
Data Source: BioPlex,STRINGDB
TGFBR2
Tchem
Family: Kinase
Novelty: 0.00085381
p_int: 0.88394082
p_ni: 0.11605918
Score: 0.379
Data Source: BioPlex,STRINGDB
DTWD2
Tdark
Novelty: 0.51908474
p_int: 0.880411283
p_ni: 0.119588717
Score: 0.221
Data Source: BioPlex,STRINGDB
MAS1
Tchem
Family: GPCR
Novelty: 0.0089712
p_int: 0.801578481
p_ni: 0.198421518
p_wrong: 1e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
STK36
Tbio
Family: Kinase
Novelty: 0.0963277
p_int: 0.796815033
p_ni: 0.203184967
Data Source: BioPlex
PTGER3
Tclin
Family: GPCR
Novelty: 0.0012681
p_int: 0.790933678
p_ni: 0.209066321
p_wrong: 1e-9
Score: 0.265
Data Source: BioPlex,STRINGDB
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.783664344
p_ni: 0.216335656
Score: 0.344
Data Source: BioPlex,STRINGDB
IL4R
Tclin
Novelty: 0.00359183
p_int: 0.768729154
p_ni: 0.231270846
Score: 0.271
Data Source: BioPlex,STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.996
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  30470.22

PubMed score by year
PubTator Score  19665.93

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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