Tbio CDH2 Cadherin-2

Protein Summary

Description

Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P19022
• A8MWK3
• B0YIY6
• Q14923
• Q8N173

Gene Name

• CDH2

Ensembl ID

• ENST00000269141
• ENSP00000269141
• ENSG00000170558
• ENST00000399380
• ENSP00000382312

Symbol

• CDHN
• NCAD
• CDHN
• NCAD
• CD325
• CDw325

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
transcription factor perturbation	0.94
protein domain	0.92
disease	0.86
virus perturbation	0.85

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1585.46   (req: < 5)

Gene RIFs: 229   (req: <= 3)

Antibodies: 1516   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1585.46   (req: >= 5)

Gene RIFs: 229   (req: > 3)

Antibodies: 1516   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (81)

Reactome (10)

KEGG (2)

PathwayCommons (8)

WikiPathways (61)

Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adherens junctions interactions	31 targets	R-HSA-418990
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-cell junction organization	63 targets	R-HSA-421270
Reactome	Developmental Biology	1055 targets	R-HSA-1266738

Name	Explore in Pharos	Explore in Source
Adherens junctions interactions	31 targets	R-HSA-418990
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-cell junction organization	63 targets	R-HSA-421270
Developmental Biology	1055 targets	R-HSA-1266738

Gene Ontology Terms (64)

Functions (9)

Components (24)

Processes (31)

Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
alpha-catenin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
beta-catenin binding	Inferred from Physical Interaction (IPI)	UniProtKB
gamma-catenin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
cadherin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytoskeletal protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein homodimerization activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calcium ion binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein phosphatase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (472)

Explore Interacting Targets

1 – 10 of 472

• See Interactions on String-DB

CTNNA3

Tbio

Novelty: 0.02196369

p_int: 0.992033066

p_ni: 0.007966931

p_wrong: 3e-9

Score: 0.576

Data Source: BioPlex,STRINGDB

TAX1BP3

Tbio

Novelty: 0.01762102

p_int: 0.95758017

p_ni: 0.04241983

Data Source: BioPlex

JUP

Tbio

Novelty: 0.01122537

Score: 0.994

Data Source: STRINGDB

CTNNB1

Tchem

Novelty: 0.00008951

Score: 0.994

Data Source: Reactome,STRINGDB

GJA1

Tbio

Novelty: 0.00023576

Score: 0.99

Data Source: STRINGDB

CTNNA1

Tbio

Novelty: 0.0104485

Score: 0.989

Data Source: Reactome,STRINGDB

CTNND1

Tbio

Novelty: 0.00399968

Score: 0.983

Data Source: STRINGDB

FN1

Tchem

Novelty: 0.0000437

Score: 0.981

Data Source: STRINGDB

FGFR1

Tclin

Family: Kinase

Novelty: 0.00068893

Score: 0.979

Data Source: STRINGDB

AXIN1

Tbio

Novelty: 0.00280253

Score: 0.975

Data Source: STRINGDB

Publication Statistics

PubMed Score  1585.46

PubMed score by year

Reset Zoom

PubTator Score  1246.21

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Sequence

MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQ

1-70

YESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLTEESVKESAEVEE

70-140

IVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIF

140-210

IINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGS

210-280

KPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQ

280-350

ATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVY

350-420

RISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVID

420-490

VNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLD

490-560

RESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPDPNSINITALDYDI

560-630

DPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKV

630-700

CQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNI

700-770

LKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGL

770-840

KAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD

840-906

MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVKLSLKPTLTEESVKESAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD

Find similar targets by:

Uniprot Keyword

Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Glycoprotein
Membrane
Metal-binding