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Tbio
SPG7
Paraplegin

Protein Summary
Description
ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (PubMed:26387735). This gene encodes a mitochondrial metalloprotease protein that is a member of the AAA family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Mutations in this gene cause autosomal recessive spastic paraplegia 7. Two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341316
  • ENSP00000341157
  • ENSG00000197912
  • ENST00000645818
  • ENSP00000495795
  • ENST00000646263
  • ENSP00000494119

Symbol
  • CAR
  • CMAR
  • PGN
  • CAR
  • PGN
  • CMAR
  • SPG5C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
0.96
transcription factor binding site profile
0.91
transcription factor perturbation
0.88
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.91   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.91   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
86
1
1
0
1.2
84.2
1
1
0
1.2
82.1
smoking initiation
1
1
1
66.3
heel bone mineral density
2
1
2
60.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
86
0
1.2
84.2
0
1.2
82.1
smoking initiation
1
66.3
heel bone mineral density
2
60.8
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Processing of SMDT1
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Processing of SMDT1
Transport of small molecules
Protein-Protein Interactions (217)
1 – 10 of 217
MAS1
Tchem
Family: GPCR
Novelty: 0.0089712
p_int: 0.99817486
p_ni: 0.00182514
Data Source: BioPlex
NDUFB9
Tclin
Family: Enzyme
Novelty: 0.00715628
p_int: 0.996819252
p_ni: 0.003175909
p_wrong: 0.000004839
Score: 0.241
Data Source: BioPlex,STRINGDB
LPAR4
Tchem
Family: GPCR
Novelty: 0.02200758
p_int: 0.992807012
p_ni: 0.007192987
Data Source: BioPlex
LPCAT4
Tdark
Family: Enzyme
Novelty: 0.246654
p_int: 0.991863423
p_ni: 0.008136577
Score: 0.212
Data Source: BioPlex,STRINGDB
ISLR
Tbio
Novelty: 0.02936208
p_int: 0.954486633
p_ni: 0.045513367
Data Source: BioPlex
PHETA1
Tbio
Novelty: 0.52415295
p_int: 0.947207147
p_ni: 0.052792853
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
CPA5
Tbio
Family: Enzyme
Novelty: 0.0516555
p_int: 0.878983469
p_ni: 0.121016512
p_wrong: 1.9e-8
Score: 0.215
Data Source: BioPlex,STRINGDB
FAM174A
Tdark
Novelty: 0.30693139
p_int: 0.873509477
p_ni: 0.126490509
p_wrong: 1.3e-8
Data Source: BioPlex
HDAC10
Tclin
Family: Epigenetic
Novelty: 0.00976829
p_int: 0.864235519
p_ni: 0.135762501
p_wrong: 0.00000198
Score: 0.195
Data Source: BioPlex,STRINGDB
CD79A
Tbio
Novelty: 0.00118942
p_int: 0.808052759
p_ni: 0.191947212
p_wrong: 2.8e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  278.91

PubMed score by year
PubTator Score  151.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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