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Tbio
CBFA2T3
Protein CBFA2T3

Protein Summary
Description
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed: ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268679
  • ENSP00000268679
  • ENSG00000129993
  • ENST00000327483
  • ENSP00000332122

Symbol
  • MTG16
  • MTGR2
  • ZMYND4
  • ETO2
  • MTG16
  • MTGR2
  • ZMYND4
  • RUNX1T3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.92
PubMedID
0.85
gene perturbation
0.75
protein domain
0.73
transcription factor binding site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.01   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.01   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
82.7
hair color
1
1
0
3
80.4
neutrophil count
2
1
2
62.6
neuroticism measurement
1
1
0
5.6
55.3
common carotid intimal medial thickness
1
1
1
38.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
82.7
hair color
0
3
80.4
neutrophil count
2
62.6
neuroticism measurement
0
5.6
55.3
common carotid intimal medial thickness
1
38.4
Protein-Protein Interactions (74)
1 – 10 of 74
PRDM14
Tbio
Family: TF; Epigenetic
Novelty: 0.01776592
p_int: 0.99996719
p_ni: 5.3e-8
p_wrong: 0.000032757
Score: 0.595
Data Source: BioPlex,STRINGDB
TCF4
Tbio
Family: TF
Novelty: 0.0019718
p_int: 0.999292837
p_ni: 6.7e-8
p_wrong: 0.000707096
Score: 0.907
Data Source: BioPlex,STRINGDB
ERBB4
Tclin
Family: Kinase
Novelty: 0.00112919
Score: 0.923
Data Source: STRINGDB
TCF12
Tbio
Family: TF
Novelty: 0.00381424
Score: 0.891
Data Source: STRINGDB
TCF3
Tbio
Family: TF
Novelty: 0.00112675
Score: 0.881
Data Source: STRINGDB
PRKAR2A
Tbio
Family: Enzyme
Novelty: 0.06183318
Score: 0.837
Data Source: STRINGDB
TAL1
Tbio
Family: TF
Novelty: 0.00294416
Score: 0.833
Data Source: STRINGDB
ZNF652
Tbio
Family: TF
Novelty: 0.09423783
Score: 0.806
Data Source: STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.799
Data Source: STRINGDB
LDB1
Tbio
Novelty: 0.01110112
Score: 0.775
Data Source: STRINGDB
Publication Statistics
PubMed Score  88.01

PubMed score by year
PubTator Score  62.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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