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Tchem
PMM2
Phosphomannomutase 2

Protein Classes
Protein Summary
Description
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268261
  • ENSP00000268261
  • ENSG00000140650
  • ENST00000566604
  • ENSP00000456774

Symbol
  • PMI
  • CDG1
  • CDGS
  • PMI1
  • CDG1a
  • PMM 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.76
transcription factor binding site profile
0.76
tissue
0.64
gene perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.15   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.15   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL51085
chemical structure image
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective PMM2 causes PMM2-CDG (CDG-1a)
Reactome
Disease
Reactome
Diseases associated with glycosylation precursor biosynthesis
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective PMM2 causes PMM2-CDG (CDG-1a)
Disease
Diseases associated with glycosylation precursor biosynthesis
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (89)
1 – 10 of 89
PMM1
Tbio
Family: Enzyme
Novelty: 0.032216
p_int: 1
Score: 0.902
Data Source: BioPlex,STRINGDB
MPI
Tchem
Family: Enzyme
Novelty: 0.00966817
Score: 0.987
Data Source: STRINGDB
GMPPB
Tbio
Family: Enzyme
Novelty: 0.05566338
Score: 0.969
Data Source: STRINGDB
GMPPA
Tbio
Family: Enzyme
Novelty: 0.02186598
Score: 0.937
Data Source: STRINGDB
HK1
Tchem
Family: Kinase
Novelty: 0.00089993
Score: 0.925
Data Source: STRINGDB
HK3
Tbio
Family: Kinase
Novelty: 0.02597641
Score: 0.915
Data Source: STRINGDB
HKDC1
Tbio
Family: Kinase
Novelty: 0.02926931
Score: 0.911
Data Source: STRINGDB
HK2
Tchem
Family: Kinase
Novelty: 0.00222818
Score: 0.911
Data Source: STRINGDB
ALG2
Tbio
Family: Enzyme
Novelty: 0.04124015
Score: 0.85
Data Source: STRINGDB
DPAGT1
Tbio
Family: Enzyme
Novelty: 0.00248803
Score: 0.836
Data Source: STRINGDB
Publication Statistics
PubMed Score  131.15

PubMed score by year
PubTator Score  158.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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