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Tclin
IGF1R
Insulin-like growth factor 1 receptor

Protein Summary
Description
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downs ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268035
  • ENSP00000268035
  • ENSG00000140443
  • ENST00000650285
  • ENSP00000497069

Symbol
  • IGFR
  • CD221
  • IGFIR
  • JTK13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
protein domain
1
biological term
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3142.17   (req: < 5)
Gene RIFs: 835   (req: <= 3)
Antibodies: 2145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3142.17   (req: >= 5)
Gene RIFs: 835   (req: > 3)
Antibodies: 2145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 841
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Active Ligands (841)
1 – 10 of 841
CHEMBL509032
chemical structure image
CHEMBL2031893
chemical structure image
CHEMBL464552
chemical structure image
CHEMBL3348846
chemical structure image
CHEMBL1091644
chemical structure image
CHEMBL3735648
chemical structure image
CHEMBL458997
chemical structure image
CHEMBL3397300
chemical structure image
compound 19a [PMID: 30503936]
chemical structure image
CHEMBL575448
chemical structure image
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
2
5
95.7
smoking status measurement
2
2
2
91.8
body height
5
3
5
88.8
birth weight
2
2
2
82.8
uric acid measurement
3
3
4
81.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
95.7
smoking status measurement
2
91.8
body height
5
88.8
birth weight
2
82.8
uric acid measurement
4
81.9
Protein Data Bank (25)
1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (71)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Extra-nuclear estrogen signaling
Reactome
IGF1R signaling cascade
Reactome
IRS-related events triggered by IGF1R
Reactome
SHC-related events triggered by IGF1R
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Extra-nuclear estrogen signaling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Gene Ontology Terms (45)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (417)
1 – 10 of 417
UNC5CL
Tbio
Novelty: 0.11511991
p_int: 0.989072607
p_ni: 0.010927393
Score: 0.23
Data Source: BioPlex,STRINGDB
IGF2
Tbio
Novelty: 0.00021277
p_int: 0.960395684
p_ni: 0.039604316
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
PATE1
Tbio
Novelty: 0.0705075
p_int: 0.887566401
p_ni: 0.112433599
Data Source: BioPlex
LYZL2
Tdark
Family: Enzyme
Novelty: 0.50542161
p_int: 0.874475365
p_ni: 0.125524635
Score: 0.179
Data Source: BioPlex,STRINGDB
SLAMF1
Tbio
Novelty: 0.00112892
p_int: 0.770239779
p_ni: 0.22976022
Score: 0.211
Data Source: BioPlex,STRINGDB
HYOU1
Tbio
Novelty: 0.00833649
p_int: 0.755785307
p_ni: 0.244214693
Data Source: BioPlex
IGF1
Tbio
Novelty: 0.00003878
Score: 0.999
Data Source: Reactome,STRINGDB
PTPN1
Tchem
Family: Enzyme
Novelty: 0.00065779
Score: 0.999
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.998
Data Source: STRINGDB
IRS1
Tbio
Novelty: 0.00048281
Score: 0.997
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  3142.17

PubMed score by year
PubTator Score  2259.33

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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