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Tbio
TINF2
TERF1-interacting nuclear factor 2

Protein Summary
Description
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267415
  • ENSP00000267415
  • ENSG00000092330
  • ENST00000399423
  • ENSP00000382350
  • ENST00000559969
  • ENSP00000452800
  • ENST00000642408
  • ENSP00000495309
  • ENSG00000284915
  • ENST00000642983
  • ENSP00000494089
  • ENST00000646576
  • ENSP00000495019

Symbol
  • TIN2
  • TIN2
  • DKCA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.8
biological process
0.79
cellular component
0.72
transcription factor binding site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.17   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.17   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cell Cycle
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cell Cycle
Cellular Senescence
Cellular responses to external stimuli
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (105)
1 – 10 of 105
ACD
Tbio
Novelty: 0.00356212
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
TERF1
Tbio
Family: TF
Novelty: 0.00225772
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
POT1
Tbio
Novelty: 0.01479724
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
TERF2
Tbio
Family: TF
Novelty: 0.00506782
p_int: 0.999995901
p_ni: 0.000004099
Score: 0.999
Data Source: BioPlex,STRINGDB
TERF2IP
Tchem
Novelty: 0.15366791
p_int: 0.998218405
p_ni: 0.001781595
Score: 0.993
Data Source: BioPlex,STRINGDB
C10orf88
Tdark
Novelty: 0.68515498
p_int: 0.974776597
p_ni: 0.025223402
p_wrong: 2e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
TNKS
Tchem
Family: Enzyme
Novelty: 0.00134534
p_int: 0.838197221
p_ni: 0.161802407
p_wrong: 3.72e-7
Score: 0.861
Data Source: BioPlex,STRINGDB
DCLRE1B
Tbio
Family: Enzyme
Novelty: 0.06282082
Score: 0.989
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00014684
Score: 0.967
Data Source: STRINGDB
STAG1
Tbio
Novelty: 0.00325752
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score  111.17

PubMed score by year
PubTator Score  86.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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