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Tbio
PXN
Paxillin

Protein Summary
Description
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228307
  • ENSP00000228307
  • ENSG00000089159
  • ENST00000267257
  • ENSP00000267257
  • ENST00000424649
  • ENSP00000391283
  • ENST00000458477
  • ENSP00000395536
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase
1
biological term
0.96
ligand (protein) perturbation
0.96
biological process
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1162.86   (req: < 5)
Gene RIFs: 157   (req: <= 3)
Antibodies: 1482   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1162.86   (req: >= 5)
Gene RIFs: 157   (req: > 3)
Antibodies: 1482   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
2
2
52
mean corpuscular volume
1
1
1
15.7
platelet count
1
1
1
15
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
52
mean corpuscular volume
1
15.7
platelet count
1
15
Protein Data Bank (21)
1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (80)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Reactome
GAB1 signalosome
Reactome
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
GAB1 signalosome
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Gene Ontology Terms (26)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (395)
1 – 10 of 395
RABGGTB
Tbio
Family: Enzyme
Novelty: 0.06786314
p_int: 0.999999662
p_ni: 3.37e-7
Score: 0.173
Data Source: BioPlex,STRINGDB
PTPN12
Tchem
Family: Enzyme
Novelty: 0.01333491
p_int: 0.999999323
p_ni: 6.42e-7
p_wrong: 3.5e-8
Score: 0.862
Data Source: BioPlex,STRINGDB
ZAR1L
Tdark
Novelty: 0.08793345
p_int: 0.999968377
p_ni: 0.000030234
p_wrong: 0.000001388
Data Source: BioPlex
EXOSC8
Tbio
Family: Enzyme
Novelty: 0.02013403
p_int: 0.999210114
p_ni: 0.000507659
p_wrong: 0.000282227
Score: 0.221
Data Source: BioPlex,STRINGDB
PTK2B
Tclin
Family: Kinase
Novelty: 0.00174314
Score: 0.999
Data Source: STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
Score: 0.999
Data Source: Reactome,STRINGDB
BCAR1
Tbio
Novelty: 0.00329214
Score: 0.999
Data Source: STRINGDB
VCL
Tbio
Novelty: 0.00043107
Score: 0.999
Data Source: STRINGDB
PARVA
Tbio
Novelty: 0.02736601
Score: 0.999
Data Source: Reactome,STRINGDB
PARVB
Tbio
Novelty: 0.03825772
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  1162.86

PubMed score by year
PubTator Score  283.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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