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Tbio
VPS37B
Vacuolar protein sorting-associated protein 37B

Protein Summary
Description
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267202
  • ENSP00000267202
  • ENSG00000139722
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
interacting protein
0.86
cellular component
0.67
gene perturbation
0.63
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.93   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.93   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (15)
Assembly Of The HIV Virion (R-HSA-175474)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly Of The HIV Virion
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Assembly Of The HIV Virion
Autophagy
Budding and maturation of HIV virion
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (52)
1 – 10 of 52
UBAP1
Tbio
Novelty: 0.02276845
p_int: 0.999999439
p_ni: 5.61e-7
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
p_int: 0.999999108
p_ni: 8.91e-7
p_wrong: 1e-9
Score: 0.525
Data Source: BioPlex,STRINGDB
VPS28
Tbio
Novelty: 0.02927315
p_int: 0.99999857
p_ni: 6.2e-8
p_wrong: 0.000001369
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TSG101
Tbio
Novelty: 0.00211746
Score: 0.999
Data Source: Reactome,STRINGDB
MVB12A
Tbio
Novelty: 0.09794
Score: 0.997
Data Source: Reactome,STRINGDB
MVB12B
Tbio
Novelty: 0.15964868
Score: 0.994
Data Source: Reactome,STRINGDB
VPS4A
Tbio
Novelty: 0.01508121
Score: 0.979
Data Source: STRINGDB
VPS36
Tbio
Novelty: 0.03382542
Score: 0.972
Data Source: Reactome,STRINGDB
VPS25
Tbio
Novelty: 0.03002488
Score: 0.97
Data Source: Reactome,STRINGDB
CHMP6
Tbio
Novelty: 0.02931
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.93

PubMed score by year
PubTator Score  0.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer