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Tbio
VPS33A
Vacuolar protein sorting-associated protein 33A

Protein Summary
Description
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267199
  • ENSP00000267199
  • ENSG00000139719

Symbol
  • MPSPS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
histone modification site profile
0.93
transcription factor binding site profile
0.77
tissue sample
0.71
cell line
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.26   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.26   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
66.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
66.7
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (129)
1 – 10 of 129
VPS16
Tbio
Novelty: 0.03575558
p_int: 0.99999665
p_ni: 0.00000335
Score: 0.999
Data Source: BioPlex,STRINGDB
VPS41
Tbio
Novelty: 0.08480171
p_int: 0.99993487
p_ni: 0.00006513
Score: 0.999
Data Source: BioPlex,STRINGDB
SRSF2
Tbio
Novelty: 0.00207072
p_int: 0.991847892
p_ni: 0.008152108
Data Source: BioPlex
VPS18
Tbio
Novelty: 0.00726539
Score: 0.999
Data Source: STRINGDB
VPS11
Tbio
Novelty: 0.00496411
Score: 0.999
Data Source: STRINGDB
VPS39
Tbio
Novelty: 0.02172601
Score: 0.996
Data Source: STRINGDB
STX12
Tbio
Novelty: 0.03836262
Score: 0.963
Data Source: STRINGDB
VIPAS39
Tbio
Novelty: 0.02348642
Score: 0.962
Data Source: STRINGDB
TGFBRAP1
Tbio
Novelty: 0.05996919
Score: 0.961
Data Source: STRINGDB
VPS8
Tbio
Novelty: 0.05178496
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.26

PubMed score by year
PubTator Score  5.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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