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Tdark
TMTC3
Transmembrane and TPR repeat-containing protein 3

Protein Summary
Description
Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response. This gene encodes a protein that belongs to the transmembrane and tetratricopeptide repeat-containing protein family. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266712
  • ENSP00000266712
  • ENSG00000139324

Symbol
  • LIS8
  • SMILE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
microRNA
0.87
kinase perturbation
0.84
transcription factor perturbation
0.84
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.33   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.33   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
4
0
1.2
80.4
red blood cell density measurement
1
1
1
30.8
mean reticulocyte volume
1
1
1
6.9
erythrocyte count
1
1
1
4.4
lymphocyte percentage of leukocytes
1
1
1
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.2
80.4
red blood cell density measurement
1
30.8
mean reticulocyte volume
1
6.9
erythrocyte count
1
4.4
lymphocyte percentage of leukocytes
1
0.3
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (47)
1 – 10 of 47
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.999628636
p_ni: 0.000371233
p_wrong: 1.32e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
HTR3C
Tchem
Family: IC
Novelty: 0.112097
p_int: 0.998493784
p_ni: 0.001506216
Score: 0.498
Data Source: BioPlex,STRINGDB
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.996264699
p_ni: 0.003735294
p_wrong: 6e-9
Data Source: BioPlex
ZACN
Tchem
Family: IC
Novelty: 0.21891621
p_int: 0.976824246
p_ni: 0.023175754
p_wrong: 1e-9
Score: 0.566
Data Source: BioPlex,STRINGDB
PCDHB1
Tdark
Novelty: 0.93001191
p_int: 0.970313498
p_ni: 0.029686502
Data Source: BioPlex
CHRND
Tclin
Family: IC
Novelty: 0.0441685
p_int: 0.962871347
p_ni: 0.037128653
Score: 0.453
Data Source: BioPlex,STRINGDB
KLRC4
Tbio
Novelty: 0.16922525
p_int: 0.958446624
p_ni: 0.041553376
Data Source: BioPlex
LYZL2
Tdark
Family: Enzyme
Novelty: 0.50542161
p_int: 0.956691766
p_ni: 0.043308234
Data Source: BioPlex
ADAM18
Tdark
Family: Enzyme
Novelty: 0.22622379
p_int: 0.952919428
p_ni: 0.047080572
Data Source: BioPlex
SCN3B
Tbio
Family: IC
Novelty: 0.0438123
p_int: 0.942054724
p_ni: 0.057945276
Score: 0.418
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.33

PubMed score by year
PubTator Score  623.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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