You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
PDE6H
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Protein Classes
Protein Summary
Description
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266395
  • ENSP00000266395
  • ENSG00000139053

Symbol
  • RCD3
  • ACHM6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
gene perturbation
0.81
cell type or tissue
0.78
kinase perturbation
0.6
biological process
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.13   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.13   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dipyridamole
chemical structure image
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 6H
VGNC:5527
742049
Mouse
MGI:1925850
78600
Rat
RGD:70933
114248
Dog
phosphodiesterase 6H
VGNC:44362
611031
Horse
phosphodiesterase 6H
VGNC:21253
100629178
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 6H
Mouse
Rat
Dog
phosphodiesterase 6H
Horse
phosphodiesterase 6H
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13956-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (103)
1 – 10 of 103
PDE6C
Tclin
Family: Enzyme
Novelty: 0.02239368
Score: 0.992
Data Source: STRINGDB
GNAT2
Tbio
Novelty: 0.01683655
Score: 0.986
Data Source: STRINGDB
PDE6A
Tclin
Family: Enzyme
Novelty: 0.02680494
Score: 0.984
Data Source: STRINGDB
CNGB3
Tchem
Family: IC
Novelty: 0.01174942
Score: 0.982
Data Source: STRINGDB
PDE6B
Tclin
Family: Enzyme
Novelty: 0.001105
Score: 0.977
Data Source: STRINGDB
CNGA3
Tchem
Family: IC
Novelty: 0.00818181
Score: 0.976
Data Source: STRINGDB
RGS9
Tbio
Novelty: 0.06662559
Score: 0.935
Data Source: STRINGDB
KCNV2
Tclin
Family: IC
Novelty: 0.02600406
Score: 0.929
Data Source: STRINGDB
GNB5
Tbio
Novelty: 0.0067714
Score: 0.918
Data Source: STRINGDB
RGS9BP
Tbio
Novelty: 0.04608613
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.13

PubMed score by year
PubTator Score  6.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer