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Tbio
REXO2
Oligoribonuclease, mitochondrial

Protein Summary
Description
3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling. This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265881
  • ENSP00000265881
  • ENSG00000076043
  • ENST00000611665
  • ENSP00000480535

Symbol
  • SFN
  • SMFN
  • RFN
  • SFN
  • REX2
  • CGI-114
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
virus perturbation
0.99
disease perturbation
0.93
cellular component
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.76   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.76   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA exonuclease 2
VGNC:1025
451561
Macaque
RNA exonuclease 2
695292
Mouse
MGI:1888981
104444
Rat
RGD:1304874
300689
Dog
RNA exonuclease 2
VGNC:45490
489395
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA exonuclease 2
Macaque
RNA exonuclease 2
Mouse
Rat
Dog
RNA exonuclease 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y3B8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (77)
1 – 10 of 77
REXO1
Tdark
Family: Enzyme
Novelty: 0.23817911
Score: 0.964
Data Source: STRINGDB
REXO5
Tdark
Family: Enzyme
Novelty: 0.8782494
Score: 0.904
Data Source: STRINGDB
REXO4
Tbio
Family: Enzyme
Novelty: 0.0328295
Score: 0.83
Data Source: STRINGDB
NHP2
Tbio
Novelty: 0.01414024
Score: 0.789
Data Source: STRINGDB
EXO1
Tbio
Family: Enzyme
Novelty: 0.00130104
Score: 0.764
Data Source: STRINGDB
ELAC2
Tbio
Family: Enzyme
Novelty: 0.01234318
Score: 0.754
Data Source: STRINGDB
SSBP1
Tbio
Novelty: 0.01105839
Score: 0.747
Data Source: STRINGDB
LRFN3
Tdark
Novelty: 0.30018245
Score: 0.703
Data Source: STRINGDB
POLR2L
Tbio
Family: Enzyme
Novelty: 0.03847579
Score: 0.702
Data Source: STRINGDB
POLR2I
Tbio
Family: Enzyme
Novelty: 0.03100605
Score: 0.688
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.76

PubMed score by year
PubTator Score  262.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer