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Tbio
PMS2
Mismatch repair endonuclease PMS2

Protein Summary
Description
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in cas ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265849
  • ENSP00000265849
  • ENSG00000122512
  • ENST00000382321
  • ENSP00000371758
  • ENST00000643595
  • ENSP00000494497

Symbol
  • PMSL2
  • MLH4
  • PMSL2
  • HNPCC4
  • PMS2CL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.97
histone modification site profile
0.81
transcription factor binding site profile
0.81
tissue sample
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 628.42   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 465   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 628.42   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 465   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Defective Mismatch Repair Associated With MLH1
Reactome
Defective Mismatch Repair Associated With PMS2
Reactome
Disease
Reactome
Diseases of Mismatch Repair (MMR)
Name
Explore in Pharos
Explore in Source
DNA Repair
Defective Mismatch Repair Associated With MLH1
Defective Mismatch Repair Associated With PMS2
Disease
Diseases of Mismatch Repair (MMR)
Protein-Protein Interactions (148)
1 – 10 of 148
MLH1
Tbio
Novelty: 0.00034212
p_int: 1
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
MSH2
Tbio
Novelty: 0.00054283
Score: 0.999
Data Source: Reactome,STRINGDB
MSH6
Tbio
Family: Epigenetic
Novelty: 0.00097439
Score: 0.999
Data Source: Reactome,STRINGDB
MSH3
Tbio
Novelty: 0.0036266
Score: 0.998
Data Source: Reactome,STRINGDB
EXO1
Tbio
Family: Enzyme
Novelty: 0.00130104
Score: 0.997
Data Source: Reactome,STRINGDB
PCNA
Tchem
Novelty: 0.03909539
Score: 0.965
Data Source: Reactome,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.963
Data Source: STRINGDB
FAN1
Tbio
Family: Enzyme
Novelty: 0.05719629
Score: 0.931
Data Source: STRINGDB
ERCC1
Tbio
Novelty: 0.00079472
Score: 0.928
Data Source: STRINGDB
BRIP1
Tbio
Novelty: 0.03886334
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  628.42

PubMed score by year
PubTator Score  426.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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