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Tbio
SH2D4A
SH2 domain-containing protein 4A

Protein Summary
Description
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265807
  • ENSP00000265807
  • ENSG00000104611
  • ENST00000518040
  • ENSP00000429482
  • ENST00000519207
  • ENSP00000428684

Symbol
  • PPP1R38
  • SH2A
  • SH2A
  • PPP1R38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
tissue sample
0.66
histone modification site profile
0.64
transcription factor
0.56
transcription factor binding site profile
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
2
34.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
34.7
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (46)
1 – 10 of 46
CTTN
Tbio
Novelty: 0.0017962
p_int: 0.998265538
p_ni: 0.001730969
p_wrong: 0.000003493
Data Source: BioPlex
PPP1R7
Tbio
Family: Enzyme
Novelty: 0.02088568
p_int: 0.996487611
p_ni: 0.003512389
Score: 0.869
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.994708554
p_ni: 0.005288465
p_wrong: 0.000002981
Data Source: BioPlex
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
p_int: 0.953437664
p_ni: 0.046562336
Score: 0.644
Data Source: BioPlex,STRINGDB
PPP1CB
Tbio
Family: Enzyme
Novelty: 0.0122614
p_int: 0.947007934
p_ni: 0.052992066
Score: 0.847
Data Source: BioPlex,STRINGDB
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.9295805
p_ni: 0.0704195
Data Source: BioPlex
TF
Tbio
Novelty: 0.00231826
p_int: 0.903004084
p_ni: 0.096995916
Score: 0.204
Data Source: BioPlex,STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.754401807
p_ni: 0.245598193
Score: 0.668
Data Source: BioPlex,STRINGDB
CCDC15
Tdark
Novelty: 1.32419957
Score: 0.781
Data Source: STRINGDB
IFI30
Tbio
Family: Enzyme
Novelty: 0.00939681
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.00

PubMed score by year
PubTator Score  7.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer