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Tchem
SMARCA2
Probable global transcription activator SNF2L2

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contai ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349721
  • ENSP00000265773
  • ENSG00000080503
  • ENST00000357248
  • ENSP00000349788
  • ENST00000382194
  • ENSP00000371629
  • ENST00000382203
  • ENSP00000371638

Symbol
  • BAF190B
  • BRM
  • SNF2A
  • SNF2L2
  • BRM
  • SNF2
  • SWI2
  • hBRM
  • NCBRS
  • Sth1p
  • BAF190
  • SNF2L2
  • SNF2LA
  • hSNF2a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
PubMedID
0.99
hub protein
0.96
disease perturbation
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.35   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.35   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
2
46.2
sex hormone-binding globulin measurement
1
1
1
42.7
thyroid volume
1
1
1
35.2
1
1
1
35.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
2
46.2
sex hormone-binding globulin measurement
1
42.7
thyroid volume
1
35.2
1
35.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
696973
Mouse
MGI:99603
67155
Rat
RGD:1302988
361745
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
VGNC:46529
476335
Horse
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
VGNC:23318
100058279
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Mouse
Rat
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Horse
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51531-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
RMTs methylate histone arginines
Gene Ontology Terms (26)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (322)
1 – 10 of 322
SS18
Tbio
Novelty: 0.00915548
p_int: 0.999999282
p_ni: 7.18e-7
Score: 0.946
Data Source: BioPlex,STRINGDB
DPF2
Tbio
Family: Epigenetic
Novelty: 0.0403366
p_int: 0.999998985
p_ni: 0.000001015
Score: 0.914
Data Source: BioPlex,STRINGDB
DPF3
Tbio
Family: Epigenetic
Novelty: 0.069151
p_int: 0.999998698
p_ni: 0.000001302
Score: 0.978
Data Source: BioPlex,STRINGDB
BCL7C
Tdark
Novelty: 0.31203802
p_int: 0.999995391
p_ni: 0.000004609
Score: 0.877
Data Source: BioPlex,STRINGDB
SMARCD1
Tbio
Novelty: 0.03176642
p_int: 0.999990724
p_ni: 0.000009276
Score: 0.997
Data Source: BioPlex,STRINGDB
SMARCC2
Tbio
Family: TF; Epigenetic
Novelty: 0.02625321
p_int: 0.99998106
p_ni: 0.00001894
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SMARCB1
Tbio
Novelty: 0.00116387
p_int: 0.999961758
p_ni: 0.000038242
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BCL7A
Tbio
Novelty: 0.07026394
p_int: 0.999761752
p_ni: 0.000238248
Score: 0.864
Data Source: BioPlex,STRINGDB
SMARCE1
Tbio
Family: TF
Novelty: 0.01748089
p_int: 0.999472462
p_ni: 0.000527538
Score: 0.997
Data Source: BioPlex,STRINGDB
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.986646686
p_ni: 0.013353314
Score: 0.151
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  382.35

PubMed score by year
PubTator Score  124.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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