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Tbio
TCIRG1
V-type proton ATPase 116 kDa subunit a isoform 3

Protein Summary
Description
Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265686
  • ENSP00000265686
  • ENSG00000110719
  • ENST00000532635
  • ENSP00000434407

Symbol
  • ATP6N1C
  • ATP6V0A3
  • a3
  • Stv1
  • Vph1
  • Atp6i
  • OC116
  • OPTB1
  • TIRC7
  • ATP6N1C
  • ATP6V0A3
  • OC-116kDa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
biological process
0.94
transcription factor perturbation
0.94
virus perturbation
0.88
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.11   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.11   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
3
80.7
reticulocyte count
1
1
1
16.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
80.7
reticulocyte count
1
16.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
VGNC:7655
466895
Macaque
T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3
710650
Mouse
MGI:1350931
27060
Rat
RGD:735136
293650
Dog
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
VGNC:47203
483691
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
Macaque
T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3
Mouse
Rat
Dog
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13488-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (26)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Protein-Protein Interactions (111)
1 – 10 of 111
ATP6V0D2
Tbio
Family: Enzyme
Novelty: 0.0354396
p_int: 0.999920001
p_ni: 0.000079999
Score: 0.997
Data Source: BioPlex,STRINGDB
ATP6V0D1
Tbio
Family: Enzyme
Novelty: 0.05146108
p_int: 0.999677511
p_ni: 0.000322151
p_wrong: 3.38e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
ATP6AP2
Tbio
Novelty: 0.00357665
p_int: 0.999542202
p_ni: 0.000457798
Score: 0.931
Data Source: BioPlex,STRINGDB
ATP6V1B1
Tchem
Family: Enzyme
Novelty: 0.01122589
Score: 0.999
Data Source: STRINGDB
ATP6V1D
Tbio
Family: Enzyme
Novelty: 0.02298626
Score: 0.996
Data Source: STRINGDB
ATP6V1E1
Tbio
Family: Enzyme
Novelty: 0.04832113
Score: 0.995
Data Source: STRINGDB
ATP6V1H
Tbio
Family: Enzyme
Novelty: 0.04269105
Score: 0.989
Data Source: STRINGDB
ATP6V1A
Tbio
Family: Enzyme
Novelty: 0.00921474
Score: 0.989
Data Source: STRINGDB
ATP6V1B2
Tchem
Family: Enzyme
Novelty: 0.01767911
Score: 0.988
Data Source: STRINGDB
ATP6V1F
Tbio
Family: Enzyme
Novelty: 0.07109314
Score: 0.987
Data Source: STRINGDB
Publication Statistics
PubMed Score  142.11

PubMed score by year
PubTator Score  139.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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