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Tchem
CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

Protein Summary
Description
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism. The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265641
  • ENSP00000265641
  • ENSG00000110090
  • ENST00000376618
  • ENSP00000365803
  • ENST00000539743
  • ENSP00000446108
  • ENST00000540367
  • ENSP00000439084

Symbol
  • CPT1
  • CPT1
  • CPT1-L
  • L-CPT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
interacting protein
0.99
biological process
0.95
disease perturbation
0.93
PubMedID
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.38   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 397   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.38   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 466
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipid measurement
1
1
1
60.7
triglyceride measurement
2
2
2
60
serum metabolite measurement
2
1
8
47.9
high density lipoprotein cholesterol measurement
1
1
1
45
apolipoprotein A 1 measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipid measurement
1
60.7
triglyceride measurement
2
60
serum metabolite measurement
8
47.9
high density lipoprotein cholesterol measurement
1
45
apolipoprotein A 1 measurement
1
38.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (33)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Reactome
Fatty acid metabolism
Reactome
Import of palmitoyl-CoA into the mitochondrial matrix
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Circadian Clock
Fatty acid metabolism
Import of palmitoyl-CoA into the mitochondrial matrix
Metabolism
Metabolism of lipids
Protein-Protein Interactions (177)
1 – 10 of 177
TBC1D9
Tbio
Novelty: 0.20059899
p_int: 0.986565908
p_ni: 0.013434092
Score: 0.252
Data Source: BioPlex,STRINGDB
HSPD1
Tbio
Novelty: 0.00018924
p_int: 0.945709047
p_ni: 0.054290954
Data Source: BioPlex
CD1A
Tbio
Novelty: 0.00090676
p_int: 0.860037889
p_ni: 0.139962111
Data Source: BioPlex
IFNLR1
Tbio
Novelty: 0.01990628
p_int: 0.856892325
p_ni: 0.143107675
Data Source: BioPlex
HLA-DQB1
Tbio
Novelty: 0.00197952
p_int: 0.853049534
p_ni: 0.146950466
Data Source: BioPlex
CMTM8
Tbio
Novelty: 0.0953768
p_int: 0.799464767
p_ni: 0.200535233
Data Source: BioPlex
PCDHGC5
Tdark
Novelty: 0.39651826
p_int: 0.799424284
p_ni: 0.200575716
Data Source: BioPlex
GABRG2
Tclin
Family: IC
Novelty: 0.00819163
p_int: 0.792853045
p_ni: 0.207146955
Score: 0.282
Data Source: BioPlex,STRINGDB
UQCC2
Tbio
Family: Enzyme
Novelty: 0.02059646
p_int: 0.78624377
p_ni: 0.21375592
p_wrong: 3.1e-7
Data Source: BioPlex
ACOX1
Tbio
Family: Enzyme
Novelty: 0.00473427
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  358.38

PubMed score by year
PubTator Score  263.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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