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Tchem
TRPV5
Transient receptor potential cation channel subfamily V member 5

Protein Summary
Description
Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000442623
  • ENSP00000406572
  • ENSG00000127412

Symbol
  • ECAC1
  • CAT2
  • ECAC1
  • OTRPC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.7
biological term
0.55
cell line
0.53
phenotype
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.49   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.49   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
ruthenium red
no chemical structure image available
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
47
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
47
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily V member 5
VGNC:14104
463800
Macaque
transient receptor potential cation channel subfamily V member 5
705218
Mouse
MGI:2429764
194352
Rat
RGD:620636
116469
Dog
transient receptor potential cation channel subfamily V member 5
VGNC:47885
100855561
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily V member 5
Macaque
transient receptor potential cation channel subfamily V member 5
Mouse
Rat
Dog
transient receptor potential cation channel subfamily V member 5
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NQA5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (73)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (90)
1 – 10 of 90
UHRF1
Tbio
Family: Epigenetic
Novelty: 0.00482565
p_int: 0.999741611
p_ni: 0.00025838
p_wrong: 8e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
p_int: 0.999243042
p_ni: 0.000756958
Score: 0.201
Data Source: BioPlex,STRINGDB
PUS1
Tbio
Family: Enzyme
Novelty: 0.01923618
p_int: 0.997533593
p_ni: 0.002466407
Score: 0.225
Data Source: BioPlex,STRINGDB
RPIA
Tbio
Family: Enzyme
Novelty: 0.00968705
p_int: 0.995142468
p_ni: 0.002894207
p_wrong: 0.001963326
Score: 0.19
Data Source: BioPlex,STRINGDB
UBE3A
Tbio
Family: Enzyme
Novelty: 0.00149368
p_int: 0.989367351
p_ni: 0.010621961
p_wrong: 0.000010689
Score: 0.204
Data Source: BioPlex,STRINGDB
GCLM
Tbio
Family: Enzyme
Novelty: 0.00395815
p_int: 0.965431228
p_ni: 0.001727511
p_wrong: 0.032841261
Score: 0.207
Data Source: BioPlex,STRINGDB
ATF1
Tchem
Family: TF
Novelty: 0.01450941
p_int: 0.963090246
p_ni: 0.000332277
p_wrong: 0.036577477
Score: 0.207
Data Source: BioPlex,STRINGDB
YY1
Tbio
Family: TF
Novelty: 0.00120891
p_int: 0.954340886
p_ni: 0.045293936
p_wrong: 0.000365178
Score: 0.19
Data Source: BioPlex,STRINGDB
NUP35
Tbio
Novelty: 0.0355102
p_int: 0.923107725
p_ni: 0.076892218
p_wrong: 5.7e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
RNF138
Tbio
Family: TF
Novelty: 0.07543428
p_int: 0.912969698
p_ni: 0.067037279
p_wrong: 0.019993023
Score: 0.19
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  181.49

PubMed score by year
PubTator Score  113.14

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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