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Tbio
RAB7A
Ras-related protein Rab-7a

Protein Summary
Description
Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the l ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265062
  • ENSP00000265062
  • ENSG00000075785

Symbol
  • RAB7
  • RAB7
  • PRO2706
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
transcription factor perturbation
0.98
biological process
0.96
kinase perturbation
0.96
disease perturbation
0.93


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 488.26   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 488.26   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB7A, member RAS oncogene family
VGNC:9694
470919
Mouse
MGI:105068
19349
Rat
RGD:61908
29448
Dog
RAB7A, member RAS oncogene family
VGNC:45293
404007
Horse
RAB7A, member RAS oncogene family
VGNC:22126
100050015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB7A, member RAS oncogene family
Mouse
Rat
Dog
RAB7A, member RAS oncogene family
Horse
RAB7A, member RAS oncogene family
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P51149-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (111)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Innate Immune System
Reactome
MHC class II antigen presentation
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Innate Immune System
MHC class II antigen presentation
Membrane Trafficking
Gene Ontology Terms (47)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
ParkinsonsUK-UCL
Protein-Protein Interactions (470)
1 – 10 of 470
GDI1
Tbio
Novelty: 0.01710945
p_int: 0.999035973
p_ni: 0.000964027
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
RILP
Tbio
Novelty: 0.08339816
Score: 0.998
Data Source: Reactome,STRINGDB
MON1A
Tbio
Novelty: 0.04537045
Score: 0.995
Data Source: Reactome,STRINGDB
MON1B
Tbio
Novelty: 0.13486379
Score: 0.995
Data Source: STRINGDB
RAB5A
Tbio
Family: Enzyme
Novelty: 0.00111347
Score: 0.992
Data Source: STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
Score: 0.991
Data Source: Reactome,STRINGDB
CCZ1
Tbio
Novelty: 0.09830652
Score: 0.99
Data Source: Reactome,STRINGDB
CCZ1B
Tdark
Novelty: 0.09724624
Score: 0.99
Data Source: STRINGDB
RAB1A
Tbio
Family: Enzyme
Novelty: 0.00307527
Score: 0.99
Data Source: STRINGDB
RAB5C
Tbio
Family: Enzyme
Novelty: 0.02952779
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score  488.26

PubMed score by year
PubTator Score  45.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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