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Tbio
MCM2
DNA replication licensing factor MCM2

Protein Summary
Description
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key compo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265056
  • ENSP00000265056
  • ENSG00000073111

Symbol
  • BM28
  • CCNL1
  • CDCL1
  • KIAA0030
  • BM28
  • CCNL1
  • CDCL1
  • cdc19
  • DFNA70
  • D3S3194
  • MITOTIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
drug perturbation
1
hub protein
0.99
kinase perturbation
0.99
molecular function
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.09   (req: < 5)
Gene RIFs: 102   (req: <= 3)
Antibodies: 933   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.09   (req: >= 5)
Gene RIFs: 102   (req: > 3)
Antibodies: 933   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
24
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
24
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the pre-replicative complex
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (24)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (371)
1 – 10 of 371
ASF1A
Tchem
Novelty: 0.02544466
p_int: 0.999906511
p_ni: 0.000093489
Score: 0.964
Data Source: BioPlex,STRINGDB
ASF1B
Tbio
Novelty: 0.05716701
p_int: 0.999904186
p_ni: 0.000095814
Score: 0.987
Data Source: BioPlex,STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.998722848
p_ni: 0.001277152
Score: 0.631
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.998605988
p_ni: 0.001394012
Score: 0.282
Data Source: BioPlex,STRINGDB
SSRP1
Tbio
Family: TF
Novelty: 0.0143993
p_int: 0.995231201
p_ni: 0.004768799
Score: 0.961
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
p_int: 0.994157829
p_ni: 0.005842171
Score: 0.635
Data Source: BioPlex,STRINGDB
HIST1H3A
Tbio
Novelty: 0.00991842
p_int: 0.990541691
p_ni: 0.009458309
Score: 0.421
Data Source: BioPlex,STRINGDB
MCM3
Tbio
Novelty: 0.00593382
p_int: 0.965239348
p_ni: 0.034760652
Score: 0.999
Data Source: BioPlex,STRINGDB
H2AFY2
Tbio
Novelty: 0.09948698
p_int: 0.953946841
p_ni: 0.046053159
Score: 0.178
Data Source: BioPlex,STRINGDB
SPIN2B
Tdark
Novelty: 0.23202718
p_int: 0.939784089
p_ni: 0.060215911
Score: 0.519
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  345.09

PubMed score by year
PubTator Score  298.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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