Protein Summary
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]
- ENST00000264914
- ENSP00000264914
- ENSG00000113273
- ENST00000396151
- ENSP00000379455
- ASB
- G4S
- MPS6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
trait | 1 | ||
biological process | 0.84 | ||
small molecule perturbation | 0.83 | ||
cellular component | 0.8 | ||
transcription factor binding site profile | 0.78 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 299.81 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 281 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 299.81 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 281 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (24)
Reactome (20)
KEGG (3)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 20
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | CS/DS degradation | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Disease | ||||
Reactome | Diseases of carbohydrate metabolism | ||||
Reactome | Diseases of metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
CS/DS degradation | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Disease | ||||
Diseases of carbohydrate metabolism | ||||
Diseases of metabolism | ||||
Gene Ontology Terms (27)
Functions (3)
Components (11)
Processes (13)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (144)
1 – 10 of 144
ERP29
Novelty: 0.01607061
p_int: 0.999677985
p_ni: 0.000321886
p_wrong: 1.3e-7
Score: 0.273
Data Source: BioPlex,STRINGDB
DEFA1
Novelty: 0.01616437
p_int: 0.999433313
p_ni: 0.000566407
p_wrong: 2.8e-7
Data Source: BioPlex
PTPRK
Family: Enzyme
Novelty: 0.03472453
p_int: 0.999390122
p_ni: 0.000602194
p_wrong: 0.000007684
Score: 0.161
Data Source: BioPlex,STRINGDB
INSL5
Novelty: 0.03673832
p_int: 0.998911531
p_ni: 0.001088434
p_wrong: 3.5e-8
Data Source: BioPlex
NAAA
Family: Enzyme
Novelty: 0.00198736
p_int: 0.994824816
p_ni: 0.005006623
p_wrong: 0.000168561
Score: 0.271
Data Source: BioPlex,STRINGDB
PLAUR
Family: Enzyme
Novelty: 0.00096649
p_int: 0.994295415
p_ni: 0.005680963
p_wrong: 0.000023621
Data Source: BioPlex
LCN6
Novelty: 0.06664903
p_int: 0.992782279
p_ni: 0.007027482
p_wrong: 0.000190239
Data Source: BioPlex
RLN1
Novelty: 0.05712331
p_int: 0.992150279
p_ni: 0.007251418
p_wrong: 0.000598303
Data Source: BioPlex
AVP
Novelty: 0.0001163
p_int: 0.991530233
p_ni: 0.008415469
p_wrong: 0.000054297
Score: 0.181
Data Source: BioPlex,STRINGDB
SIAE
Family: Enzyme
Novelty: 0.00505798
p_int: 0.97764758
p_ni: 0.022267184
p_wrong: 0.000085236
Score: 0.622
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 299.81
PubMed score by year
PubTator Score 401.53
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTP
1-70
HLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTT
70-140
HMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMY
140-210
STNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNV
210-280
TAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHI
280-350
SDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP
350-420
EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSRE
420-490
YPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
490-533
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
Find similar targets by: