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Tchem
F13A1
Coagulation factor XIII A chain

Protein Summary
Description
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264870
  • ENSP00000264870
  • ENSG00000124491

Symbol
  • F13A
  • F13A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
gene perturbation
0.96
biological term
0.93
protein domain
0.92
disease
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.17   (req: < 5)
Gene RIFs: 170   (req: <= 3)
Antibodies: 1204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.17   (req: >= 5)
Gene RIFs: 170   (req: > 3)
Antibodies: 1204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 72
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.4
26.3
age at onset
1
1
0
5.4
26.3
glucose-dependent insulinotropic peptide measurement
1
1
1
1
glucose tolerance test
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.4
26.3
age at onset
0
5.4
26.3
glucose-dependent insulinotropic peptide measurement
1
1
glucose tolerance test
1
1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor XIII A chain
VGNC:7888
462413
Macaque
coagulation factor XIII A chain
711264
Mouse
MGI:1921395
74145
Rat
RGD:621495
60327
Dog
coagulation factor XIII A chain
VGNC:40545
478711
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor XIII A chain
Macaque
coagulation factor XIII A chain
Mouse
Rat
Dog
coagulation factor XIII A chain
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00488-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Common Pathway of Fibrin Clot Formation (R-HSA-140875)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Cytokine Signaling in Immune system
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Common Pathway of Fibrin Clot Formation
Cytokine Signaling in Immune system
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Immune System
Protein-Protein Interactions (131)
1 – 10 of 131
F13B
Tbio
Novelty: 0.00562478
Score: 0.985
Data Source: Reactome,STRINGDB
FGA
Tbio
Novelty: 0.00107227
Score: 0.971
Data Source: STRINGDB
FGG
Tbio
Novelty: 0.00404457
Score: 0.969
Data Source: STRINGDB
F2
Tclin
Family: Enzyme
Novelty: 0.00004833
Score: 0.964
Data Source: Reactome,STRINGDB
FGB
Tbio
Novelty: 0.00437751
Score: 0.956
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.954
Data Source: STRINGDB
SERPINF2
Tbio
Novelty: 0.00054719
Score: 0.953
Data Source: STRINGDB
VWF
Tbio
Novelty: 0.00009007
Score: 0.95
Data Source: STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.944
Data Source: STRINGDB
F5
Tbio
Novelty: 0.00161772
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  152.17

PubMed score by year
PubTator Score  487.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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