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Tbio
KLF1
Krueppel-like factor 1

Protein Summary
Description
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation. This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264834
  • ENSP00000264834
  • ENSG00000105610

Symbol
  • EKLF
  • EKLF
  • EKLF/KLF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.8
biological process
0.76
disease perturbation
0.68
hub protein
0.67
molecular function
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 293.9   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 382   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 293.9   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
2
2
2
89
mean corpuscular hemoglobin concentration
2
2
2
86.9
body mass index
1
1
1
57.1
reticulocyte measurement
1
2
2
56.2
reticulocyte count
4
1
4
18.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
2
89
mean corpuscular hemoglobin concentration
2
86.9
body mass index
1
57.1
reticulocyte measurement
2
56.2
reticulocyte count
4
18.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 1
VGNC:13193
468741
Macaque
Kruppel like factor 1
716842
Mouse
MGI:1342771
16596
Rat
RGD:1309398
304666
Dog
Kruppel like factor 1
VGNC:42430
484924
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 1
Macaque
Kruppel like factor 1
Mouse
Rat
Dog
Kruppel like factor 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13351-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (17)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (87)
1 – 10 of 87
GATA1
Tbio
Family: TF
Novelty: 0.00077901
Score: 0.928
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.912
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.872
Data Source: STRINGDB
ALAS2
Tbio
Family: Enzyme
Novelty: 0.00491418
Score: 0.868
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.864
Data Source: STRINGDB
HBG1
Tbio
Novelty: 0.00384136
Score: 0.805
Data Source: STRINGDB
HBG2
Tbio
Novelty: 0.01145628
Score: 0.8
Data Source: STRINGDB
EPB42
Tbio
Family: Enzyme
Novelty: 0.06393286
Score: 0.784
Data Source: STRINGDB
AHSP
Tbio
Novelty: 0.00996928
Score: 0.781
Data Source: STRINGDB
NFE2
Tbio
Family: TF
Novelty: 0.00321017
Score: 0.774
Data Source: STRINGDB
Publication Statistics
PubMed Score  293.90

PubMed score by year
PubTator Score  167.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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