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Tbio
OLFM2
Noelin-2

Protein Summary
Description
Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264833
  • ENSP00000264833
  • ENSG00000105088

Symbol
  • NOE2
  • NOE2
  • OlfC
  • NOELIN2
  • NOELIN2_V1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
tissue sample
0.66
cell type or tissue
0.51
transcription factor
0.5
cell line
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.85   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.85   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
1
1
62.8
sleep duration
1
1
1
46.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
62.8
sleep duration
1
46.2
Gene Ontology Terms (13)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (95)
1 – 10 of 95
OLFM1
Tbio
Novelty: 0.02210029
p_int: 0.999977962
p_ni: 0.000022038
Score: 0.603
Data Source: BioPlex,STRINGDB
ZFHX4
Tbio
Family: TF
Novelty: 0.06538087
p_int: 0.999956383
p_ni: 0.000043612
p_wrong: 5e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
RNF40
Tbio
Family: Enzyme
Novelty: 0.07038528
p_int: 0.99973586
p_ni: 0.00026414
Data Source: BioPlex
CXCL5
Tbio
Novelty: 0.00286795
p_int: 0.999390542
p_ni: 0.000602776
p_wrong: 0.000006682
Data Source: BioPlex
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.999126694
p_ni: 0.000873303
p_wrong: 2e-9
Data Source: BioPlex
DVL2
Tbio
Novelty: 0.00833084
p_int: 0.997038219
p_ni: 0.002423926
p_wrong: 0.000537855
Data Source: BioPlex
FEM1B
Tbio
Novelty: 0.06746412
p_int: 0.993288784
p_ni: 0.006711215
p_wrong: 1e-9
Data Source: BioPlex
OLFM3
Tbio
Novelty: 0.10234408
p_int: 0.990743423
p_ni: 0.003635792
p_wrong: 0.005620785
Score: 0.506
Data Source: BioPlex,STRINGDB
KDM5C
Tchem
Family: TF; Epigenetic
Novelty: 0.00701855
p_int: 0.989994896
p_ni: 0.009763837
p_wrong: 0.000241267
Data Source: BioPlex
MSTO1
Tbio
Novelty: 0.05914188
p_int: 0.9866314
p_ni: 0.013347598
p_wrong: 0.000021001
Data Source: BioPlex
Publication Statistics
PubMed Score  19.85

PubMed score by year
PubTator Score  10.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer