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Tbio
TP63
Tumor protein 63

Protein Summary
Description
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264731
  • ENSP00000264731
  • ENSG00000073282
  • ENST00000320472
  • ENSP00000317510
  • ENST00000354600
  • ENSP00000346614
  • ENST00000392460
  • ENSP00000376253
  • ENST00000392461
  • ENSP00000376254
  • ENST00000392463
  • ENSP00000376256
  • ENST00000418709
  • ENSP00000407144
  • ENST00000437221
  • ENSP00000392488
  • ENST00000440651
  • ENSP00000394337
  • ENST00000449992
  • ENSP00000387839
  • ENST00000456148
  • ENSP00000389485

Symbol
  • KET
  • P63
  • P73H
  • P73L
  • TP73L
  • AIS
  • KET
  • LMS
  • NBP
  • RHS
  • p40
  • p51
  • p63
  • EEC3
  • OFC8
  • p73H
  • p73L
  • SHFM4
  • TP53L
  • TP73L
  • p53CP
  • TP53CP
  • B(p51A)
  • B(p51B)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
0.97
molecular function
0.94
transcription factor perturbation
0.94
trait
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.35   (req: < 5)
Gene RIFs: 678   (req: <= 3)
Antibodies: 794   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.35   (req: >= 5)
Gene RIFs: 678   (req: > 3)
Antibodies: 794   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.2
98
5
4
0
1.2
97.1
1
1
0
1.1
67.1
adipose tissue measurement
1
1
0
54
49.7
2
1
0
1.1
39.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
98
0
1.2
97.1
0
1.1
67.1
adipose tissue measurement
0
54
49.7
0
1.1
39.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tumor protein p63
VGNC:2619
460930
Macaque
tumor protein p63
703997
Mouse
MGI:1330810
22061
Rat
RGD:620863
246334
Dog
tumor protein p63
VGNC:47729
488125
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tumor protein p63
Macaque
tumor protein p63
Mouse
Rat
Dog
tumor protein p63
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (67)
Activation of BH3-only proteins (R-HSA-114452)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of PUMA and translocation to mitochondria
Reactome
Apoptosis
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of PUMA and translocation to mitochondria
Apoptosis
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (75)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (135)
1 – 10 of 135
CHEK2
Tchem
Family: Kinase
Novelty: 0.00068355
p_int: 0.999999933
p_ni: 5.3e-8
p_wrong: 1.4e-8
Score: 0.71
Data Source: BioPlex,STRINGDB
TP73
Tbio
Family: TF
Novelty: 0.00667737
p_int: 0.999996122
p_ni: 0.000003878
Score: 0.982
Data Source: BioPlex,STRINGDB
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01454593
p_int: 0.999976228
p_ni: 0.000023772
Score: 0.202
Data Source: BioPlex,STRINGDB
RPH3A
Tbio
Family: Epigenetic
Novelty: 0.01321524
p_int: 0.999772796
p_ni: 0.000227203
Score: 0.243
Data Source: BioPlex,STRINGDB
FOXK1
Tbio
Family: TF
Novelty: 0.01321144
p_int: 0.999692971
p_ni: 0.000307029
Score: 0.174
Data Source: BioPlex,STRINGDB
FOXK2
Tbio
Family: TF
Novelty: 0.01420141
p_int: 0.996363172
p_ni: 0.003636828
Score: 0.164
Data Source: BioPlex,STRINGDB
PEX14
Tbio
Novelty: 0.0210557
p_int: 0.937288335
p_ni: 0.062711665
Score: 0.169
Data Source: BioPlex,STRINGDB
MDM2
Tchem
Family: Enzyme
Novelty: 0.00028385
Score: 0.989
Data Source: STRINGDB
PERP
Tbio
Novelty: 0.00773799
Score: 0.977
Data Source: STRINGDB
CDKN2A
Tbio
Family: Enzyme
Novelty: 0.00014147
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  301.35

PubMed score by year
PubTator Score  2096.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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