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Tbio
FGF10
Fibroblast growth factor 10

Protein Summary
Description
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264664
  • ENSP00000264664
  • ENSG00000070193
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.68
pathway
0.66
phenotype
0.64
cell line
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 488.8   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 488.8   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 107
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
1
1
56.2
forced expiratory volume
1
1
1
42.7
prostate carcinoma
2
1
0
1.1
41.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
56.2
forced expiratory volume
1
42.7
prostate carcinoma
0
1.1
41.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1099809
14165
Rat
RGD:2606
25443
Dog
fibroblast growth factor 10
VGNC:40839
612454
Horse
fibroblast growth factor 10
VGNC:18009
100052655
Pig
fibroblast growth factor 10
100525086
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
fibroblast growth factor 10
Horse
fibroblast growth factor 10
Pig
fibroblast growth factor 10
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (105)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 52
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Developmental Biology
Disease
Gene Ontology Terms (112)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (191)
1 – 10 of 191
HIST1H1A
Tbio
Novelty: 0.00123818
p_int: 0.997786647
p_ni: 0.002213353
Data Source: BioPlex
ITIH2
Tbio
Novelty: 0.04886358
p_int: 0.996760059
p_ni: 0.003239939
p_wrong: 2e-9
Score: 0.222
Data Source: BioPlex,STRINGDB
RPL26L1
Tdark
Novelty: 0.75408617
p_int: 0.955181284
p_ni: 0.044818716
Data Source: BioPlex
SIRT1
Tchem
Family: Epigenetic
Novelty: 0.00022265
p_int: 0.860939249
p_ni: 0.139060751
Score: 0.203
Data Source: BioPlex,STRINGDB
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
Score: 0.998
Data Source: Reactome,STRINGDB
FGFBP1
Tbio
Novelty: 0.02117534
Score: 0.966
Data Source: Reactome,STRINGDB
FGFRL1
Tbio
Novelty: 0.02178846
Score: 0.966
Data Source: STRINGDB
FGFR1
Tclin
Family: Kinase
Novelty: 0.00055714
Score: 0.963
Data Source: STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.959
Data Source: STRINGDB
FRS2
Tbio
Novelty: 0.00654052
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  488.80

PubMed score by year
PubTator Score  198.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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