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Tchem
FGF2
Fibroblast growth factor 2

Protein Summary
Description
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with disti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000608478
  • ENSP00000477134
  • ENSG00000138685
  • ENST00000614010
  • ENSP00000478620
  • ENST00000644866
  • ENSP00000494222

Symbol
  • FGFB
  • BFGF
  • FGFB
  • FGF-2
  • HBGF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
0.96
pathway
0.8
disease
0.78
microRNA
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13050.31   (req: < 5)
Gene RIFs: 627   (req: <= 3)
Antibodies: 1047   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13050.31   (req: >= 5)
Gene RIFs: 627   (req: > 3)
Antibodies: 1047   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 60
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (21)
1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (124)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 83
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Developmental Biology
Disease
Gene Ontology Terms (65)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
MGI
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (647)
1 – 10 of 647
IL7R
Tbio
Novelty: 0.00107223
p_int: 0.999999774
p_ni: 2.2e-7
p_wrong: 6e-9
Data Source: BioPlex
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
p_int: 0.999999577
p_ni: 4.23e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
SDC2
Tbio
Novelty: 0.00597758
p_int: 0.999999424
p_ni: 5.61e-7
p_wrong: 1.5e-8
Score: 0.974
Data Source: BioPlex,STRINGDB
CD44
Tbio
Novelty: 0.00011321
p_int: 0.999998694
p_ni: 6.1e-8
p_wrong: 0.000001246
Score: 0.89
Data Source: BioPlex,STRINGDB
SDC1
Tbio
Novelty: 0.00044792
p_int: 0.999918517
p_ni: 0.00000195
p_wrong: 0.000079534
Score: 0.981
Data Source: BioPlex,STRINGDB
TMEFF1
Tbio
Novelty: 0.11856207
p_int: 0.9994368
p_ni: 6.34e-7
p_wrong: 0.000562566
Score: 0.351
Data Source: BioPlex,STRINGDB
FGFR1
Tclin
Family: Kinase
Novelty: 0.00055714
Score: 0.998
Data Source: STRINGDB
FGFR3
Tclin
Family: Kinase
Novelty: 0.00071612
Score: 0.993
Data Source: STRINGDB
FGFR4
Tclin
Family: Kinase
Novelty: 0.00258329
Score: 0.993
Data Source: STRINGDB
HSPG2
Tbio
Family: Enzyme
Novelty: 0.00159541
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  13050.31

PubMed score by year
PubTator Score  4657.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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