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Tbio
CRYGD
Gamma-crystallin D

Protein Summary
Description
Crystallins are the dominant structural components of the vertebrate eye lens. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264376
  • ENSP00000264376
  • ENSG00000118231
  • ENST00000644920
  • ENSP00000496652
  • ENSG00000285434

Symbol
  • CRYG4
  • CCP
  • PCC
  • CACA
  • CCA3
  • CRYG4
  • CTRCT4
  • cry-g-D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
biological term
0.76
tissue
0.67
cell line
0.52
cellular component
0.49


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.82   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.82   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin gamma D
VGNC:10732
459906
Mouse
MGI:88524
12967
Rat
RGD:1586353
689947
Dog
crystallin, gamma D
488495
Cow
crystallin, gamma D
281723
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin gamma D
Mouse
Rat
Dog
crystallin, gamma D
Cow
crystallin, gamma D
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07320-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (40)
1 – 10 of 40
FOPNL
Tbio
Novelty: 0.07640992
p_int: 0.999988495
p_ni: 0.0000115
p_wrong: 5e-9
Data Source: BioPlex
CRYAA
Tbio
Novelty: 0.01914081
Score: 0.847
Data Source: STRINGDB
CRYAA2
Tdark
Novelty: 0.01914081
Score: 0.814
Data Source: STRINGDB
CRYAB
Tbio
Novelty: 0.00464213
Score: 0.805
Data Source: STRINGDB
GJA3
Tbio
Novelty: 0.00638283
Score: 0.772
Data Source: STRINGDB
GJA8
Tbio
Novelty: 0.00377739
Score: 0.76
Data Source: STRINGDB
BFSP2
Tbio
Novelty: 0.00206411
Score: 0.749
Data Source: STRINGDB
TMEM114
Tdark
Novelty: 0.25895358
Score: 0.699
Data Source: STRINGDB
BFSP1
Tbio
Novelty: 0.01519136
Score: 0.689
Data Source: STRINGDB
LIM2
Tbio
Novelty: 0.01252353
Score: 0.674
Data Source: STRINGDB
Publication Statistics
PubMed Score  399.82

PubMed score by year
PubTator Score  393.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer