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Tbio
PCDH10
Protocadherin-10

Protein Summary
Description
Potential calcium-dependent cell-adhesion protein. This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein is a cadherin-related neuronal receptor thought to function in the establishment of specific cell-cell connections in the brain. This gene plays a role in inhibiting cancer cell motility and cell migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264360
  • ENSP00000264360
  • ENSG00000138650
  • ENST00000618019
  • ENSP00000480512

Symbol
  • KIAA1400
  • PCDH19
  • OL-PCDH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
trait
0.75
transcription factor perturbation
0.74
virus perturbation
0.72
microRNA
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.7   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.7   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (65)
1 – 10 of 65
PCDHGB1
Tdark
Novelty: 0.60440805
p_int: 0.999999589
p_ni: 3.93e-7
p_wrong: 1.8e-8
Score: 0.178
Data Source: BioPlex,STRINGDB
PCDH12
Tbio
Novelty: 0.06268895
p_int: 0.999998707
p_ni: 0.000001293
Score: 0.297
Data Source: BioPlex,STRINGDB
SLC34A2
Tbio
Family: Transporter
Novelty: 0.00601743
p_int: 0.999980591
p_ni: 0.000019408
Score: 0.189
Data Source: BioPlex,STRINGDB
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.999792773
p_ni: 0.000207214
p_wrong: 1.3e-8
Data Source: BioPlex
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.99961671
p_ni: 0.000383004
p_wrong: 2.86e-7
Data Source: BioPlex
PTGIR
Tclin
Family: GPCR
Novelty: 0.0091906
p_int: 0.998612064
p_ni: 0.0013867
p_wrong: 0.000001236
Data Source: BioPlex
PCDHGB4
Tdark
Novelty: 0.25018904
p_int: 0.998439769
p_ni: 0.001560189
p_wrong: 4.2e-8
Score: 0.184
Data Source: BioPlex,STRINGDB
PCDHGB2
Tdark
Novelty: 1.16587709
p_int: 0.986631547
p_ni: 0.013368452
p_wrong: 1e-9
Data Source: BioPlex
UPK2
Tbio
Novelty: 0.01066132
p_int: 0.970584637
p_ni: 0.028566015
p_wrong: 0.000849348
Data Source: BioPlex
TMEM130
Tdark
Novelty: 1.39618601
p_int: 0.956740321
p_ni: 0.043255683
p_wrong: 0.000003996
Data Source: BioPlex
Publication Statistics
PubMed Score  107.70

PubMed score by year
PubTator Score  42.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer