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Tbio
ALS2
Alsin

Protein Summary
Description
May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264276
  • ENSP00000264276
  • ENSG00000003393
  • ENST00000467448
  • ENSP00000429223

Symbol
  • ALS2CR6
  • KIAA1563
  • ALSJ
  • PLSJ
  • IAHSP
  • ALS2CR6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
protein domain
0.92
transcription factor binding site profile
0.87
kinase perturbation
0.84
molecular function
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.51   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.51   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ALS2, alsin Rho guanine nucleotide exchange factor
VGNC:65
470613
Mouse
MGI:1921268
74018
Rat
RGD:1310372
363235
Dog
ALS2, alsin Rho guanine nucleotide exchange factor
VGNC:37819
100856109
Horse
ALS2, alsin Rho guanine nucleotide exchange factor
VGNC:15268
100066250
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ALS2, alsin Rho guanine nucleotide exchange factor
Mouse
Rat
Dog
ALS2, alsin Rho guanine nucleotide exchange factor
Horse
ALS2, alsin Rho guanine nucleotide exchange factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96Q42-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Gene Ontology Terms (38)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (79)
1 – 10 of 79
STXBP6
Tbio
Novelty: 0.13195671
p_int: 0.999999851
p_ni: 3.8e-8
p_wrong: 1.12e-7
Score: 0.205
Data Source: BioPlex,STRINGDB
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.999999315
p_ni: 6.84e-7
Score: 0.201
Data Source: BioPlex,STRINGDB
NEK1
Tchem
Family: Kinase
Novelty: 0.0164923
p_int: 0.999998737
p_ni: 0.000001263
Score: 0.473
Data Source: BioPlex,STRINGDB
SDF2
Tbio
Novelty: 0.02591549
p_int: 0.999983235
p_ni: 0.000016765
Score: 0.356
Data Source: BioPlex,STRINGDB
CFAP410
Tbio
Novelty: 0.0143773
p_int: 0.999524722
p_ni: 0.000474961
p_wrong: 3.17e-7
Score: 0.275
Data Source: BioPlex,STRINGDB
RBM6
Tbio
Novelty: 0.06349982
p_int: 0.985468192
p_ni: 0.014531362
p_wrong: 4.46e-7
Score: 0.231
Data Source: BioPlex,STRINGDB
ATG4C
Tbio
Family: Enzyme
Novelty: 0.04175533
p_int: 0.970737588
p_ni: 0.029262259
p_wrong: 1.53e-7
Data Source: BioPlex
RAB5A
Tbio
Family: Enzyme
Novelty: 0.00111347
Score: 0.982
Data Source: STRINGDB
RAB5C
Tbio
Family: Enzyme
Novelty: 0.02952779
Score: 0.945
Data Source: STRINGDB
RAB5B
Tbio
Family: Enzyme
Novelty: 0.02653775
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  143.51

PubMed score by year
PubTator Score  75.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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