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Tbio
CPOX
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

Protein Classes
Protein Summary
Description
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264193
  • ENSP00000264193
  • ENSG00000080819
  • ENST00000647941
  • ENSP00000497326

Symbol
  • CPO
  • CPX
  • COX
  • CPO
  • CPX
  • HCP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
transcription factor perturbation
0.74
histone modification site profile
0.73
microRNA
0.71
tissue
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.02   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.02   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coproporphyrinogen oxidase
VGNC:1789
460544
Mouse
MGI:104841
12892
Rat
RGD:1311817
304024
Dog
coproporphyrinogen oxidase
VGNC:53070
487948
Horse
coproporphyrinogen oxidase [Source:HGNC Symbol;Acc:HGNC:2321]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coproporphyrinogen oxidase
Mouse
Rat
Dog
coproporphyrinogen oxidase
Horse
coproporphyrinogen oxidase [Source:HGNC Symbol;Acc:HGNC:2321]
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (18)
Heme biosynthesis (R-HSA-189451)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Heme biosynthesis
Reactome
Metabolism
Reactome
Metabolism of porphyrins
Name
Explore in Pharos
Explore in Source
Heme biosynthesis
Metabolism
Metabolism of porphyrins
Protein-Protein Interactions (78)
1 – 10 of 78
UROD
Tbio
Family: Enzyme
Novelty: 0.00337791
Score: 0.998
Data Source: STRINGDB
PPOX
Tchem
Family: Enzyme
Novelty: 0.00652809
Score: 0.997
Data Source: STRINGDB
FECH
Tbio
Family: Enzyme
Novelty: 0.00282289
Score: 0.963
Data Source: STRINGDB
UROS
Tbio
Family: Enzyme
Novelty: 0.00938683
Score: 0.962
Data Source: STRINGDB
HMBS
Tbio
Family: Enzyme
Novelty: 0.00193847
Score: 0.948
Data Source: STRINGDB
ALAD
Tbio
Family: Enzyme
Novelty: 0.00092757
Score: 0.945
Data Source: STRINGDB
ALAS2
Tbio
Family: Enzyme
Novelty: 0.00491418
Score: 0.843
Data Source: STRINGDB
ALAS1
Tclin
Family: Enzyme
Novelty: 0.00965779
Score: 0.837
Data Source: STRINGDB
SQLE
Tchem
Family: Enzyme
Novelty: 0.0059338
Score: 0.797
Data Source: STRINGDB
TWNK
Tbio
Novelty: 0.00393371
Score: 0.714
Data Source: STRINGDB
Publication Statistics
PubMed Score  88.02

PubMed score by year
PubTator Score  106.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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