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Tchem
FCER2
Low affinity immunoglobulin epsilon Fc receptor

Protein Classes
Protein Summary
Description
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346664
  • ENSP00000264072
  • ENSG00000104921
  • ENST00000597921
  • ENSP00000471974

Symbol
  • CD23A
  • CLEC4J
  • FCE2
  • IGEBF
  • CD23
  • FCE2
  • CD23A
  • IGEBF
  • CLEC4J
  • BLAST-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
cell type or tissue
0.65
protein domain
0.58
gene perturbation
0.56
tissue sample
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 458.19   (req: < 5)
Gene RIFs: 90   (req: <= 3)
Antibodies: 1493   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 458.19   (req: >= 5)
Gene RIFs: 90   (req: > 3)
Antibodies: 1493   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
3.3
monocyte percentage of leukocytes
1
1
1
1.9
leukocyte count
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
3.3
monocyte percentage of leukocytes
1
1.9
leukocyte count
1
0.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fc fragment of IgE receptor II
456434
Mouse
MGI:95497
14128
Rat
RGD:619997
171075
Dog
Fc fragment of IgE receptor II
VGNC:49895
484998
Horse
Fc fragment of IgE receptor II
VGNC:17974
100009715
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fc fragment of IgE receptor II
Mouse
Rat
Dog
Fc fragment of IgE receptor II
Horse
Fc fragment of IgE receptor II
Protein Data Bank (23)
1 – 5 of 23
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
NOTCH2 intracellular domain regulates transcription
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
NOTCH2 intracellular domain regulates transcription
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (60)
1 – 10 of 60
STAT6
Tchem
Family: TF
Novelty: 0.00096732
Score: 0.944
Data Source: STRINGDB
NOTCH2
Tchem
Novelty: 0.00195617
Score: 0.933
Data Source: STRINGDB
IL13
Tbio
Novelty: 0.00021435
Score: 0.926
Data Source: STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.919
Data Source: STRINGDB
RBPJ
Tbio
Family: TF
Novelty: 0.00168834
Score: 0.917
Data Source: STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.905
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.903
Data Source: STRINGDB
MAML2
Tbio
Novelty: 0.00836375
Score: 0.9
Data Source: STRINGDB
MAML3
Tbio
Novelty: 0.05574812
Score: 0.9
Data Source: STRINGDB
MAMLD1
Tbio
Novelty: 0.01681081
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  458.19

PubMed score by year
PubTator Score  969.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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