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Tbio
FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

Protein Summary
Description
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264042
  • ENSP00000264042
  • ENSG00000006607
  • ENST00000373287
  • ENSP00000362384
  • ENST00000627550
  • ENSP00000486597

Symbol
  • KIAA0793
  • PLEKHC3
  • FIR
  • FRG
  • PLEKHC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
cell line
0.72
kinase perturbation
0.71
tissue sample
0.7
cell type or tissue
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.1   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.1   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
92.4
self reported educational attainment
1
1
1
67.2
prostate carcinoma
2
1
0
1.1
66.4
low density lipoprotein cholesterol measurement
1
1
1
65.7
fibrinogen measurement
2
1
2
63.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
92.4
self reported educational attainment
1
67.2
prostate carcinoma
0
1.1
66.4
low density lipoprotein cholesterol measurement
1
65.7
fibrinogen measurement
2
63.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FERM, ARH/RhoGEF and pleckstrin domain protein 2
VGNC:426
460083
Macaque
FERM, ARH/RhoGEF and pleckstrin domain protein 2
701179
Mouse
MGI:2385126
227377
Rat
RGD:1308003
316639
Dog
FERM, ARH/RhoGEF and pleckstrin domain protein 2
VGNC:40731
486205
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FERM, ARH/RhoGEF and pleckstrin domain protein 2
Macaque
FERM, ARH/RhoGEF and pleckstrin domain protein 2
Mouse
Rat
Dog
FERM, ARH/RhoGEF and pleckstrin domain protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O94887-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Semaphorin interactions
Protein-Protein Interactions (65)
1 – 10 of 65
RPS27A
Tbio
Novelty: 0.00658124
p_int: 0.999981987
p_ni: 0.000018013
Data Source: BioPlex
TRIM41
Tbio
Family: Enzyme
Novelty: 0.17238173
p_int: 0.999957048
p_ni: 0.000042952
Data Source: BioPlex
GPR156
Tdark
Family: GPCR
Novelty: 0.39183023
p_int: 0.999923862
p_ni: 0.000076138
Data Source: BioPlex
TACR3
Tchem
Family: GPCR
Novelty: 0.00351352
p_int: 0.999923549
p_ni: 0.000076409
p_wrong: 4.2e-8
Data Source: BioPlex
CLNS1A
Tbio
Novelty: 0.01824362
p_int: 0.999832166
p_ni: 0.000167834
Score: 0.186
Data Source: BioPlex,STRINGDB
PSD2
Tdark
Novelty: 0.03272803
p_int: 0.999428878
p_ni: 0.000571103
p_wrong: 1.9e-8
Data Source: BioPlex
PRMT5
Tchem
Family: Epigenetic
Novelty: 0.00395474
p_int: 0.999149228
p_ni: 0.000850772
Data Source: BioPlex
MISP
Tbio
Novelty: 0.02030151
p_int: 0.998729583
p_ni: 0.001264753
p_wrong: 0.000005664
Data Source: BioPlex
PIP
Tbio
Novelty: 0.00208509
p_int: 0.998390325
p_ni: 0.001609672
p_wrong: 3e-9
Data Source: BioPlex
PTGER3
Tclin
Family: GPCR
Novelty: 0.0012681
p_int: 0.997912485
p_ni: 0.002087431
p_wrong: 8.4e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  9.10

PubMed score by year
PubTator Score  113.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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