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Tbio
NECTIN1
Nectin-1

Protein Summary
Description
Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity. (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV. This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264025
  • ENSP00000264025
  • ENSG00000110400
  • ENST00000340882
  • ENSP00000345289
  • ENST00000341398
  • ENSP00000344974

Symbol
  • HVEC
  • PRR1
  • PVRL1
  • ED4
  • PRR
  • HIgR
  • HV1S
  • HVEC
  • OFC7
  • PRR1
  • PVRR
  • CD111
  • PVRL1
  • PVRR1
  • SK-12
  • CLPED1
  • nectin-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.7   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.7   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Nectin/Necl trans heterodimerization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Nectin/Necl trans heterodimerization
Gene Ontology Terms (38)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
HGNC
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (62)
1 – 10 of 62
NECTIN3
Tbio
Novelty: 0.01288113
p_int: 0.99983781
p_ni: 3e-9
p_wrong: 0.000162186
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.997569148
p_ni: 0.000001679
p_wrong: 0.002429173
Score: 0.278
Data Source: BioPlex,STRINGDB
AFDN
Tbio
Novelty: 0.00372947
Score: 0.979
Data Source: Reactome,STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.966
Data Source: STRINGDB
NECTIN4
Tclin
Novelty: 0.00694563
Score: 0.946
Data Source: Reactome,STRINGDB
PVR
Tbio
Novelty: 0.00215811
Score: 0.943
Data Source: STRINGDB
NECTIN2
Tbio
Novelty: 0.00910836
Score: 0.923
Data Source: Reactome,STRINGDB
CADM3
Tbio
Novelty: 0.01907524
Score: 0.921
Data Source: Reactome,STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.92
Data Source: STRINGDB
CTNNA1
Tbio
Novelty: 0.00925774
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  311.70

PubMed score by year
PubTator Score  192.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer