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Tbio
CDH3
Cadherin-3

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264012
  • ENSP00000264012
  • ENSG00000062038
  • ENST00000429102
  • ENSP00000398485

Symbol
  • CDHP
  • CDHP
  • HJMD
  • PCAD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
gene perturbation
0.89
biological process
0.82
protein domain
0.73
biological term
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.45   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 867   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.45   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 867   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
75.3
1
1
0
1.1
31.7
1
1
0
1.1
27.7
1
1
0
1.1
27.7
1
1
0
1.1
27.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
75.3
0
1.1
31.7
0
1.1
27.7
0
1.1
27.7
0
1.1
27.6
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (56)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Gene Ontology Terms (33)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (75)
1 – 10 of 75
CTNNA3
Tbio
Novelty: 0.01472452
p_int: 0.999999981
p_ni: 6e-9
p_wrong: 1.4e-8
Score: 0.416
Data Source: BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty: 0.01605171
p_int: 0.999999911
p_ni: 8.4e-8
p_wrong: 5e-9
Data Source: BioPlex
PCDHGB1
Tdark
Novelty: 0.60440805
p_int: 0.999999733
p_ni: 2e-9
p_wrong: 2.65e-7
Score: 0.178
Data Source: BioPlex,STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.996
Data Source: STRINGDB
JUP
Tbio
Novelty: 0.0081803
Score: 0.992
Data Source: STRINGDB
CTNND1
Tbio
Novelty: 0.00335459
Score: 0.986
Data Source: STRINGDB
CTNNA1
Tbio
Novelty: 0.00925774
Score: 0.963
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.942
Data Source: STRINGDB
CDH17
Tbio
Novelty: 0.00035679
Score: 0.929
Data Source: STRINGDB
CDH8
Tbio
Novelty: 0.04055999
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  344.45

PubMed score by year
PubTator Score  141.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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