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Tbio
PKP1
Plakophilin-1

Protein Summary
Description
Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263946
  • ENSP00000263946
  • ENSG00000081277
  • ENST00000352845
  • ENSP00000295597
  • ENST00000367324
  • ENSP00000356293

Symbol
  • B6P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
gene perturbation
0.91
interacting protein
0.78
protein domain
0.73
PubMedID
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.82   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.82   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cell adhesion proteins
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Developmental Biology
Protein-Protein Interactions (86)
1 – 10 of 86
CCDC82
Tdark
Novelty: 0.48211191
p_int: 0.956247908
p_ni: 0.043752092
Score: 0.239
Data Source: BioPlex,STRINGDB
CCDC51
Tdark
Novelty: 1.19203634
p_int: 0.955807152
p_ni: 0.044192848
Score: 0.183
Data Source: BioPlex,STRINGDB
FBXL4
Tbio
Novelty: 0.04286856
p_int: 0.938678038
p_ni: 0.061321962
Score: 0.201
Data Source: BioPlex,STRINGDB
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.821324089
p_ni: 0.178675911
Data Source: BioPlex
NDUFS5
Tclin
Family: Enzyme
Novelty: 0.13274675
p_int: 0.789087757
p_ni: 0.210912243
Data Source: BioPlex
CIDEA
Tbio
Novelty: 0.00901749
p_int: 0.764375886
p_ni: 0.235624114
Score: 0.326
Data Source: BioPlex,STRINGDB
KIF3A
Tbio
Novelty: 0.00555124
p_int: 0.751777675
p_ni: 0.248222325
Score: 0.214
Data Source: BioPlex,STRINGDB
DSG1
Tbio
Novelty: 0.00142889
Score: 0.993
Data Source: STRINGDB
DSC1
Tbio
Novelty: 0.01434802
Score: 0.992
Data Source: STRINGDB
DSP
Tbio
Novelty: 0.00178018
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  98.82

PubMed score by year
PubTator Score  87.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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