You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KIF1B
Kinesin-like protein KIF1B

Protein Summary
Description
Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis. This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263934
  • ENSP00000263934
  • ENSG00000054523
  • ENST00000377081
  • ENSP00000366284
  • ENST00000377083
  • ENSP00000366287
  • ENST00000377086
  • ENSP00000366290
  • ENST00000377093
  • ENSP00000366297

Symbol
  • KIAA0591
  • KIAA1448
  • KLP
  • CMT2
  • CMT2A
  • CMT2A1
  • HMSNII
  • NBLST1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
1
molecular function
0.99
microRNA
0.96
transcription factor binding site profile
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.12   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.12   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
2
4
94
1
1
0
1.6
91.8
myeloid white cell count
1
1
1
76.9
1
1
0
1.3
75.2
neutrophil count
2
1
2
67.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
94
0
1.6
91.8
myeloid white cell count
1
76.9
0
1.3
75.2
neutrophil count
2
67.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
kinesin family member 1B
722674
Mouse
MGI:108426
16561
Rat
RGD:621520
117548
Dog
kinesin family member 1B
VGNC:42391
479605
Horse
kinesin family member 1B
VGNC:19402
100057126
Species
Name
OMA
EggNOG
Inparanoid
Macaque
kinesin family member 1B
Mouse
Rat
Dog
kinesin family member 1B
Horse
kinesin family member 1B
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60333-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Intra-Golgi and retrograde Golgi-to-ER traffic
Gene Ontology Terms (33)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (191)
1 – 10 of 191
KIF1A
Tbio
Novelty: 0.00505209
p_int: 0.99999988
p_ni: 1.19e-7
Score: 0.971
Data Source: BioPlex,STRINGDB
BIN2
Tbio
Novelty: 0.00952157
p_int: 0.999998896
p_ni: 0.000001049
p_wrong: 5.5e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
CETN1
Tbio
Novelty: 0.01208917
p_int: 0.999998614
p_ni: 0.000001385
p_wrong: 1e-9
Score: 0.263
Data Source: BioPlex,STRINGDB
KIF1BP
Tbio
Novelty: 0.03932922
p_int: 0.999997761
p_ni: 0.000002239
Score: 0.614
Data Source: BioPlex,STRINGDB
VPS33B
Tbio
Novelty: 0.02221093
p_int: 0.999982445
p_ni: 0.000017554
Score: 0.223
Data Source: BioPlex,STRINGDB
VIPAS39
Tbio
Novelty: 0.02348642
p_int: 0.999963163
p_ni: 0.000036714
p_wrong: 1.22e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
GOPC
Tbio
Novelty: 0.01110168
p_int: 0.999866404
p_ni: 0.000133595
Data Source: BioPlex
PLOD1
Tbio
Family: Enzyme
Novelty: 0.00905345
p_int: 0.999466246
p_ni: 0.000533754
Data Source: BioPlex
PDF
Tchem
Family: Enzyme
Novelty: 0.02477934
p_int: 0.994599147
p_ni: 0.005400853
Score: 0.159
Data Source: BioPlex,STRINGDB
PPP4R1
Tbio
Family: Enzyme
Novelty: 0.10822249
p_int: 0.967643931
p_ni: 0.029173334
p_wrong: 0.003182735
Score: 0.189
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  103.12

PubMed score by year
PubTator Score  129.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: