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Tbio
LNX1
E3 ubiquitin-protein ligase LNX

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263925
  • ENSP00000263925
  • ENSG00000072201
  • ENST00000306888
  • ENSP00000302879

Symbol
  • LNX
  • PDZRN2
  • LNX
  • MPDZ
  • PDZRN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.68
transcription factor perturbation
0.68
PubMedID
0.62
transcription factor
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.23   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.23   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
85.7
neutrophil count
1
1
1
51.9
balding measurement
1
1
1
51.2
cervical artery dissection
1
1
0
1.2
46.8
1
1
0
2.2
41
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
85.7
neutrophil count
1
51.9
balding measurement
1
51.2
cervical artery dissection
0
1.2
46.8
0
2.2
41
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (343)
1 – 10 of 343
LRFN4
Tbio
Novelty: 0.12511571
p_int: 0.99998718
p_ni: 0.00001282
Score: 0.236
Data Source: BioPlex,STRINGDB
NXF2
Tbio
Novelty: 0.04733504
p_int: 0.999984932
p_ni: 0.000015068
Data Source: BioPlex
LRP5
Tbio
Novelty: 0.00089807
p_int: 0.767136772
p_ni: 0.223087174
p_wrong: 0.009776054
Data Source: BioPlex
UBE2N
Tbio
Novelty: 0.00620946
Score: 0.994
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.993
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.993
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.987
Data Source: STRINGDB
NUMB
Tbio
Novelty: 0.00211228
Score: 0.983
Data Source: STRINGDB
RLIM
Tbio
Family: Enzyme
Novelty: 0.02267745
Score: 0.96
Data Source: STRINGDB
UBE2D2
Tbio
Novelty: 0.00603877
Score: 0.958
Data Source: STRINGDB
Publication Statistics
PubMed Score  69.23

PubMed score by year
PubTator Score  30.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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