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Tbio
GNLY
Granulysin

Protein Summary
Description
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263863
  • ENSP00000263863
  • ENSG00000115523
  • ENST00000409696
  • ENSP00000387116

Symbol
  • LAG2
  • NKG5
  • TLA519
  • LAG2
  • NKG5
  • LAG-2
  • D2S69E
  • TLA519
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.64
PubMedID
0.57
tissue sample
0.57
cellular component
0.53
tissue
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 535.4   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 535.4   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
granulysin
VGNC:267
459370
Horse
granulysin
VGNC:49458
100034133
Cow
uncharacterized LOC616323
616323
Pig
granulysin
396869
Species
Name
OMA
EggNOG
Inparanoid
Chimp
granulysin
Horse
granulysin
Cow
uncharacterized LOC616323
Pig
granulysin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22749-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (62)
1 – 10 of 62
PRF1
Tchem
Novelty: 0.0002835
Score: 0.953
Data Source: STRINGDB
GZMB
Tchem
Family: Enzyme
Novelty: 0.00052869
Score: 0.938
Data Source: STRINGDB
GZMA
Tbio
Family: Enzyme
Novelty: 0.00322362
Score: 0.923
Data Source: STRINGDB
GZMH
Tbio
Family: Enzyme
Novelty: 0.01480634
Score: 0.885
Data Source: STRINGDB
NKG7
Tdark
Novelty: 0.0599879
Score: 0.883
Data Source: STRINGDB
SRRT
Tbio
Novelty: 0.00429818
Score: 0.83
Data Source: STRINGDB
LAG3
Tbio
Novelty: 0.00187736
Score: 0.76
Data Source: STRINGDB
KLRD1
Tbio
Novelty: 0.00218019
Score: 0.751
Data Source: STRINGDB
IL2
Tchem
Novelty: 0.00003129
Score: 0.691
Data Source: STRINGDB
IL15
Tbio
Novelty: 0.00049351
Score: 0.685
Data Source: STRINGDB
Publication Statistics
PubMed Score  535.40

PubMed score by year
PubTator Score  222.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer