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Tdark
FNBP4
Formin-binding protein 4

Protein Summary
Description
This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle formation. Naturally occurring mutations in this gene are associated with Waardenburg anophthalmia syndrome. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263773
  • ENSP00000263773
  • ENSG00000109920
  • ENST00000646180
  • ENSP00000494562
  • ENSG00000285182

Symbol
  • FBP30
  • KIAA1014
  • FBP30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.98
drug perturbation
0.96
transcription factor binding site profile
0.93
ligand (protein) perturbation
0.83
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
1
1
87.5
chronotype measurement
1
1
1
51
alcohol consumption measurement
1
1
1
45.1
high density lipoprotein cholesterol measurement
1
1
1
39.7
body mass index
1
1
1
29.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
87.5
chronotype measurement
1
51
alcohol consumption measurement
1
45.1
high density lipoprotein cholesterol measurement
1
39.7
body mass index
1
29.4
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (52)
1 – 10 of 52
DDX17
Tbio
Family: Enzyme
Novelty: 0.00462781
p_int: 0.999999938
p_ni: 6.2e-8
Score: 0.445
Data Source: BioPlex,STRINGDB
ZC3H18
Tdark
Novelty: 0.3515546
p_int: 0.999999367
p_ni: 6.33e-7
p_wrong: 1e-9
Score: 0.403
Data Source: BioPlex,STRINGDB
DGKZ
Tbio
Family: Enzyme
Novelty: 0.01312044
p_int: 0.999998823
p_ni: 0.000001176
p_wrong: 1e-9
Data Source: BioPlex
FGF12
Tbio
Novelty: 0.02094849
p_int: 0.999996759
p_ni: 0.000003241
Data Source: BioPlex
TRAP1
Tchem
Novelty: 0.03344189
p_int: 0.97990539
p_ni: 0.015436623
p_wrong: 0.004657986
Data Source: BioPlex
ARHGAP12
Tbio
Family: Enzyme
Novelty: 0.12113722
p_int: 0.931573455
p_ni: 0.00084479
p_wrong: 0.067581755
Data Source: BioPlex
PNISR
Tdark
Novelty: 0.06559175
Score: 0.841
Data Source: STRINGDB
SRSF11
Tbio
Novelty: 0.17035604
Score: 0.788
Data Source: STRINGDB
FNBP1
Tbio
Novelty: 0.03879767
Score: 0.676
Data Source: STRINGDB
WBP4
Tbio
Novelty: 0.10095907
Score: 0.654
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.67

PubMed score by year
PubTator Score  4.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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