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Tbio
LHX4
LIM/homeobox protein Lhx4

Protein Summary
Description
May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536). This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263726
  • ENSP00000263726
  • ENSG00000121454

Symbol
  • CPHD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.7
histone modification site profile
0.61
cell line
0.6
biological process
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.28   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 344   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.28   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Regulation of expression of SLITs and ROBOs
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Regulation of expression of SLITs and ROBOs
Signaling by ROBO receptors
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (80)
1 – 10 of 80
SSBP4
Tdark
Novelty: 0.27365687
p_int: 0.999999987
p_ni: 1.3e-8
Score: 0.766
Data Source: BioPlex,STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
p_int: 0.999999798
p_wrong: 2.02e-7
Score: 0.344
Data Source: BioPlex,STRINGDB
LDB1
Tbio
Novelty: 0.01110112
p_int: 0.999947729
p_ni: 0.000052271
Score: 0.983
Data Source: BioPlex,Reactome,STRINGDB
SSBP2
Tbio
Novelty: 0.06546999
p_int: 0.999721619
p_ni: 0.00027838
p_wrong: 1e-9
Score: 0.752
Data Source: BioPlex,STRINGDB
CETN1
Tbio
Novelty: 0.01208917
p_int: 0.999577823
p_ni: 0.00001055
p_wrong: 0.000411628
Data Source: BioPlex
THAP12
Tbio
Family: TF
Novelty: 0.21092098
p_int: 0.999356819
p_ni: 0.000643181
Score: 0.518
Data Source: BioPlex,STRINGDB
ISL2
Tbio
Family: TF
Novelty: 0.03917372
p_int: 0.999311138
p_ni: 0.000687985
p_wrong: 8.78e-7
Score: 0.865
Data Source: BioPlex,STRINGDB
CHMP1A
Tbio
Novelty: 0.03969333
p_int: 0.983208204
p_ni: 0.001817604
p_wrong: 0.014974192
Data Source: BioPlex
WASF2
Tbio
Novelty: 0.00968798
p_int: 0.979158324
p_ni: 0.009618184
p_wrong: 0.011223492
Score: 0.237
Data Source: BioPlex,STRINGDB
TSC22D4
Tbio
Family: TF
Novelty: 0.25451456
p_int: 0.978397921
p_ni: 0.021594689
p_wrong: 0.000007391
Score: 0.74
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  49.28

PubMed score by year
PubTator Score  39.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer