You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LCN1
Lipocalin-1

Protein Summary
Description
Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket. This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263598
  • ENSP00000263598
  • ENSG00000160349
  • ENST00000371781
  • ENSP00000360846

Symbol
  • VEGP
  • TP
  • TLC
  • PMFA
  • VEGP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.67
interacting protein
0.61
protein domain
0.58
cell type or tissue
0.56
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.67   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.67   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of fatty acids
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of fatty acids
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Protein-Protein Interactions (53)
1 – 10 of 53
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999926425
p_ni: 0.000073575
Data Source: BioPlex
PECR
Tbio
Family: Enzyme
Novelty: 0.01550165
p_int: 0.998688093
p_ni: 0.001311907
Score: 0.513
Data Source: BioPlex,STRINGDB
PDYN
Tbio
Novelty: 0.00039564
p_int: 0.997820161
p_ni: 0.000155337
p_wrong: 0.002024502
Score: 0.311
Data Source: BioPlex,STRINGDB
SNX27
Tbio
Novelty: 0.02419724
p_int: 0.854080519
p_ni: 0.145919476
p_wrong: 6e-9
Data Source: BioPlex
DNAJB8
Tbio
Novelty: 0.0791748
p_int: 0.771089589
p_ni: 0.22891041
Score: 0.214
Data Source: BioPlex,STRINGDB
HBM
Tdark
Novelty: 0.02658671
p_int: 0.77092985
p_ni: 0.229070143
p_wrong: 7e-9
Data Source: BioPlex
LMBR1L
Tbio
Novelty: 0.19690548
Score: 0.904
Data Source: STRINGDB
KIF22
Tbio
Novelty: 0.0109594
Score: 0.74
Data Source: STRINGDB
LYZ
Tbio
Family: Enzyme
Novelty: 0.00151342
Score: 0.721
Data Source: STRINGDB
APOD
Tbio
Novelty: 0.0031899
Score: 0.718
Data Source: STRINGDB
Publication Statistics
PubMed Score  205.67

PubMed score by year
PubTator Score  108.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer